Expression analysis of thymus-dependent lymphocyte subsets and natural killer cell activity detection in patients with diffuse large B-cell lymphoma with different chemotherapy responses
LI Wenwen ZHOU Zhangjun
Department of Hematology, Xiamen Haicang Hospital, Fujian Procince, Xiamen 361000, China
Abstract：Objective To investigate the expression levels of thymus-dependent lymphocyte (T lymphocyte) subsets and natural killer (NK) cell activity in diffuse large B-cell lymphoma (DLBCL) patients with different chemotherapy responses. Methods A total of 80 DLBCL patients who received treatment in Xiamen Haicang Hospital from January 2017 to January 2021 and achieved a certain curative effect were selected as the research subjects, and they were divided into complete remission group (n=44) and partial remission group (n=36). Forty healthy subjects who underwent physical examination during the same period were selected as the control group. The differences in the detection results of T lymphocyte subsets and NK cell activity were compared between the disease group and the control group, as well as the disease group before and after chemotherapy. Results Before chemotherapy, the CD3+, CD4+, CD4+/CD8+ and NK cell activity levels in the complete remission group and the partial remission group were lower than those in the control group, and the level of CD8+ was higher than that in the control group, and the differences were statistically significant(P<0.05). After 4 cycles of chemotherapy, the CD3+, CD4+, CD4+/CD8+ and NK cell activity levels in the complete remission group were higher than those before chemotherapy and after 2 cycles of chemotherapy, and the CD8+ level was lower than those before chemotherapy and after 2 cycles of chemotherapy, the differences were statistically significant(P<0.05). There were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+and NK cell activity levels in the partial remission group before chemotherapy, after 2 and 4 cycles of chemotherapy (P>0.05). Conclusion T lymphocyte subsets and NK cell activity were significantly abnormally expressed in DLBCL patients, and their expression levels were different in response to different curative effects. The test results are helpful for evaluating the clinical curative effect of DLBCL patients and are worthy of further study.
李雯雯； 周章军. 胸腺依赖淋巴细胞亚群和自然杀伤细胞活性检测在不同化疗疗效弥漫大B细胞淋巴瘤患者中的表达分析[J]. 中国当代医药, 2022, 29(27): 63-66.
LI Wenwen ；ZHOU Zhangjun. Expression analysis of thymus-dependent lymphocyte subsets and natural killer cell activity detection in patients with diffuse large B-cell lymphoma with different chemotherapy responses. 中国当代医药, 2022, 29(27): 63-66.
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