咖啡因对早产儿支气管肺发育不良的预防效果及对血管内皮生长因子水平的影响

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摘要

[摘要]目的探讨咖啡因对早产儿支气管肺发育不良（BPD）的预防效果及对血管内皮生长因子（VEGF）水平的影响。方法选取2020年5月至2021年4月邵阳学院附属第一医院新生儿科收治的42 例早产儿作为研究对象，按照随机数字表法分为治疗组和对照组，每组21 例。对照组给予常规对症处理，治疗组在对照组的基础上给予咖啡因治疗。比较两组早产儿的住院时间、体重增长速率、需氧时间、BPD 发病率、死亡率以及出生后第1、3、7、14、21 天时外周血血清中VEGF 的表达水平。结果治疗组早产儿的住院时间和需氧时间均短于对照组，体重增长速率快于对照组，BPD 发病率低于对照组，差异有统计学意义（P＜0.05）。两组早产儿的死亡率比较，差异无统计学意义（P＞0.05）。治疗组早产儿第7、14、21 天血清中的VEGF 表达水平均低于对照组，差异有统计学意义（P＜0.05）。结论 VEGF 的表达水平与咖啡因治疗BPD 时间相关，有一定的临床意义。

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	彭新平刘瑾罗勇龙运峰廖烘李清

关键词 ：早产儿, 支气管肺发育不良, 血管内皮生长因子, 咖啡因

Abstract：

Objective To investigate the preventive effect of Caffeine on bronchopulmonary dysplasia (BPD) in premature infants and its influence on the level of vascular endothelial growth factor (VEGF). Methods A total of 42 premature infants treated in the Department of Neonatal Pediatrics of the First Affiliated Hospital of Shaoyang University from May 2020 to April 2021 were selected as the research objects, according to random number table method, they were divided into the treatment group and the control group, with 21 cases in each group. The control group was treated with routine symptomatic treatment, and the treatment group was treated with Caffeine on the basis of the control group. The hospitalization time, weight growth rate, aerobic time, incidence rate of BPD, mortality rate, and the expression level of VEGF in peripheral blood serum on 1, 3, 7, 14, 21 d after birth of the two groups were compared. Results The hospitalization time and aerobic time of the premature infants in the treatment group were shorter than those in the control group, the weight growth rate in the treatment group was faster than that in the control group, he incidence rate of BPD in the treatment group was lower than that in the control group, the differences were statistically significant (P＜0.05).There was no significant difference in mortality between the treatment group and the control group (P＞0.05). At the three time points of 7, 14, 21 d, the expression level of VEGF in the serum of premature infants in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The expression level of VEGF is related to the time of Caffeine treatment of BPD, which has a certain clinical significance

Key words： Premature infant Bronchopulmonary dysplasia Vascular endothelial growth factor Caffeine

基金资助:

湖南省教育厅科学研究项目（18C0826）。

作者简介: 彭新平（1967-），男，汉族，湖南邵东人，硕士，主任医师，主要研究方向：新生儿学。

引用本文:

彭新平刘瑾罗勇龙运峰廖烘李清. 咖啡因对早产儿支气管肺发育不良的预防效果及对血管内皮生长因子水平的影响[J]. 中国当代医药, 2022, 29(26): 120-122.
PENG Xinping LIU Jin LUO Yong LONG Yunfeng LIAO Hong LI Qing. Preventive effect of Caffeine on bronchopulmonary dysplasia in premature infants and its influence on the level of vascular endothelial growth factor. 中国当代医药, 2022, 29(26): 120-122.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I26/120

[1]	Hwang JS，Rehan VK.Recent advances in bronchopulmonary dysplasia：pathophysiology，prevention，and treatment[J].Lung，2018，196（2）：129-138.
[2]	Jobe AH. The new bronchopulmonary dysplasia[J].Curr Opin Pediatr，2011，23（2）：167-172.
[3]	刘雅竹，陈亚丹，李婷婷，等.不同剂量枸橼酸咖啡因用于早产儿呼吸暂停的疗效和安全性系统评价[J].中国医院药学杂志，2018，38（2）：173-178.
[4]	黎小兰，蔡岳鞠，张喆，等.不同维持剂量枸橼酸咖啡因对极早产儿呼吸窘迫综合征撤机影响：前瞻性随机对照研究[J].中国当代儿科杂志，2021，23（11）：1097-1102.
[5]	唐洪怡，李秋平.支气管肺发育不良“血管假说”及促血管生成治疗进展[J].临床儿科杂志，2016，34（7）：553-557.
[6]	邵肖梅，叶鸿瑁，丘小汕.实用新生儿学[M].4 版.北京：人民卫生出版社，2011.
[7]	Hansmann G，Sallmon H，Roehr CC，et al.Pulmonary hypertension in bronchopulmonary dysplasia[J].Pediatr Res，2021，89（3）：446-455.
[8]	Day CL，Ryan RM.Bronchopulmonary dysplasia：new becomes old again![J].Pediatr Res，2017，81（1-2）：210-213.
[9]	Dumpa V，Bhandari V.Non-invasive ventilatory strategies to decrease bronchopulmonary dysplasia-where are we in 2021?[J].Children （Basel），2021，8（2）：132.
[10]	傅旭明，黄烈平，韩宜姚，等.不同维持剂量枸橼酸咖啡因在早产儿呼吸暂停中的应用对比观察[J].中华全科医学，2021，19（12）：2065-2067，2076.
[11]	Lamba V，Winners O，Fort P.Early high-dose caffeine improves respiratory outcomes in preterm infants[J].Children（Basel），2021，8（6）：501.
[12]	Lodha A，Seshia M，McMillan DD，et al.Association of early caffeine administration and neonatal outcomes in very preterm neonates[J].JAMA Pediatr，2015，169（1）：33-38.
[13]	Vliegenthart R，Miedema M，Hutten GJ，et al.High versus standard dose caffeine for apnoea：a systematic review[J].Arch Dis Child Fetal Neonatal Ed，2018，103（6）：F523-F529.
[14]	Islam JY，Keller RL，Aschner JL，et al.Understanding the short-and long-term respiratory outcomes of prematurity and bronchopulmonary dysplasia[J].Am J Respir Crit Care Med，2015，192（2）：134-156.
[15]	Barratt SL，Flower VA，Pauling JD，et al.VEGF （vascular endothelial growth factor） and fibrotic lung disease[J].Int J Mol Sci，2018，19（5）：1269.
[16]	林玉芳，李秋平，封志纯.血管内皮生长因子在支气管肺发育不良方面的研究进展[J].临床儿科杂志，2016，34（11）：871-874.