Abstract：Objective To investigate the effect of Aspirin combined with Clopidogrel dual antiplatelet on anticoagulation therapy in patients with acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction admitted to the Second Affiliated Hospital of Guilin Medical College from January 2017 to December 2018 were selected as research subjects and divided into two groups by random number table method, with 40 cases in each group. The control group was treated with Aspirin alone, and the observation group was treated with Clopidogrel on the basis of the control group. The neurological function (National Institutes of Health stroke scale [NIHSS] score) and coagulation function (activated partial thromboplastin time [APTT], prothrombin time [PT], thrombin time [TT], fibrinogen [FIB] and platelet count [PLT]) were compared between the two groups before and after treatment. The incidence of adverse reactions in the two groups was also analyzed. Results After treatment, the NIHSS scores of the two groups were lower than those before treatment, and NIHSS score of the observation group was lower than that in the control group, and the differences were statistically significant (P＜0.05). After treatment, the APTT, PT and TT of the two groups were longer than those before treatment, FIB levels of the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05). There were no significant differences in APTT, PT, TT, FIB and PLT levels between the two groups after treatment (P＞0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Aspirin combined with Clopidogrel dual antiplatelet therapy can effectively improve the neurological function of patients with acute cerebral infarction, prolong their coagulation time, and protect the life and health of patients with good safety.
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