1. Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Hubei Province, Wuhan 430022, China;
2. School of Medicine, Wuhan University of Science and Technology, Hubei Province, Wuhan 430062, China
Abstract：Objective To investigate the effect of coenzyme I for injection (NAD+) on the early prognosis of elderly patients undergoing valve replacement combined with coronary artery bypass grafting. Methods A total of 54 elderly patients who underwent valve replacement combined with coronary artery bypass surgery at Wuhan Asia Heart Hospital from July 2019 to March 2020 were selected as the research objects and divided into the study group (27 cases) and the control group (27 cases) by random number table method. The control group received conventional treatment, and the study group received NAD+on the basis of conventional treatment. The left ventricular ejection fraction (LVEF), N-terminal pro-B type natriuretic peptide (NT-proBNP) levels, and the size of the heart cavity were compared between the two groups of patients before and after surgery. The occurrence of postoperative complications was observed. Re-sults 7 days after operation, the NT-proBNP in the study group was lower than that in the control group, with a statistically significant difference (P＜0.05). While, there was no significant difference in LVEF between the two groups 7 days after operation (P＞0.05). 7 days after operation, there were no significant differences in the size of left atrium and left ventricle between the two groups (P＞0.05). There were no death or second thoracotomy in the two groups after operation. In terms of other postoperative complications, atrial fibrillation occurred in 4 cases (14.81%) and pleural effusion in 18 cases (66.67%) in the study group, while atrial fibrillation occurred in 7 cases (25.92%) and pleural effusion in 23 cases (85.18%) in the control group. The incidence of postoperative complications in the study group was lower than that in the control group, but the difference was not statistically significant (P＞0.05). Conclusion The use of NAD+after valve replacement combined with coronary artery bypass surgery has a positive effect on the early prognosis of elderly patients.
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