Analysis of risk factors associated with multiple drug-resistant organisms infection in patients of intensive care unit
TIAN Wenwen1 WANG Pengxiang2 YU Weiming2 ZHANG Qianwen2 WANG Likun2▲
1. Department of Medicine, Qingdao University, Shandong Province, Qingdao 266000, China;
2. Department of Infection Control Center, Linyi People′s Hospital, Shandong Province, Linyi 276000, China
Abstract：Objective To analyze the risk factors of multiple drug-resistant organisms (MDRO) infection in intensive care unit (ICU) patients of Liangshan People′s Hospital and the clinical distribution characteristics of multi-drug resistant bacteria. Methods A total of 159 patients with bacterial infection admitted to ICU from January 2016 to June 2021 were analyzed retrospectively as research objects, including 65 cases in the sensitive bacterial infection group and 94 cases in the MDRO group. A variety of intervention factors in the two groups were statistically analyzed, such as patients′ age, gender, time in the ICU, basic diseases, surgery, conscious state, variety of antibiotic use, glucocorticoid use time, endoheal intubation time, tracheotomy, mechanical ventilation time, time of urinary catheter, gastric catheter,vasoactive drugs, blood transfusion and other factors. Results The results of univariate analysis showed that there were significant differences of the incidence of underlying diseases, hemoglobin content, procalcitonin (PCT), C-reactive protein (CRP), types of antibiotics, tracheotomy time, mechanical ventilation time and vasoactive drug use time in the MDRO group compared with the sensitive bacteria group (P<0.05). The multivariate analysis showed that the underlying diseases (β=1.156, OR=3.178, 95%CI=1.404-7.195) and the type of antibiotics (β=0.69, OR=1.995, 95%CI=1.021-3.896) were independent risk factors for multi-drug resistant bacterial infection in ICU patients (P<0.05). Most of the MDRO infection were Acinetobacter baumannii (57.447%), Pseudomonas aeruginosa (7.447%), Klebsiella pneumoniae(7.447%) and mixed bacterial infection (15.957%). The infection was mainly distributed in the lung (89.362%), outside the lung (3.191%) (such as urinary system, abdominal cavity, soft tissue and intracranial, etc.) and mixed sites(7.447%). Conclusion MDRO hospital infection is closely related to underlying diseases, type of antibiotic used, clinical attention should be paid.
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