Abstract：Objective To analyze the characteristics and risk factors of coronary artery lesions (CAL) in children with Kawasaki disease (KD), so as to provide a basis for clinical treatment and prognosis. Methods The relevant clinical data of 180 children with KD admitted to the Pediatrics Department, Yichun People′s Hospital from January 2020 to May 2021 was retrospectively analyzed. According to the presence or absence of CAL, the children were divided into observation group (combined CAL, 31 cases) and control group (non-CAL, 149 cases). Both groups were treated with intravenous gamma globulin (IVIG). Gender, age, and the start time of using IVIG were collected. Multivariate logistic analysis was performed on the data with statistical differences in univariate analysis to screen the risk factors for CAL in children with KD. Results Univariate analysis showed that age, start time of using IVIG, IVIG resistance, erythrocyte sedimentation rate (ESR), duration of fever, treatment time, C-reactive protein (CRP), alanine aminotransferase (ALT),interleukin-6 (IL-6), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and serum sodium, decreased white blood cells (WBC), neutrophil-to-lymphocyte ratio (NLR) and platelet (PLT) were compared between two groups, the differences were statistically significant (P<0.05). Multivariate logistic analysis showed that duration of fever (β=1.254,OR=3.504, 95%CI=1.272-9.653), NT-proBNP (β=0.708, OR=2.030, 95%CI=1.170-3.521), WBC (β=0.869, OR=2.385,95%CI=1.332-4.286), PLT (β=0.657, OR=1.929, 95%CI=1.361-2.734), ESR (β=1.037, OR=2.821, 95%CI=1.533-5.819), and NLR (β=0.946, OR=2.575, 95%CI=1.262-5.256) were independent risk factors for CAL in children with KD (P<0.05). Conclusion Duration of fever, NT-proBNP, WBC, NLR, PLT and ESR are risk factors for CAL in children with KD. Attention should be paid to above-mentioned indicators in clinical treatment, and effective treatment should be performed timely.
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