心理社会干预辅助齐拉西酮治疗在青少年精神分裂症中的应用效果

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摘要目的探讨心理社会干预辅助齐拉西酮治疗在青少年精神分裂症（SCH）中的应用效果。方法选取2019年7月至2020年7月营口市第四人民医院收治的88 例青少年SCH 患者作为研究对象，采用随机数字表法将其分为药物组和辅助干预组，每组44 例。药物组采用齐拉西酮口服治疗，辅助干预组则在服用齐拉西酮的基础上实施心理社会干预进行辅助治疗。比较两组患儿的临床疗效及治疗前后的自知力和社会功能。结果辅助干预组治疗后的总有效率高于药物组，差异有统计学意义（P＜0.05）。治疗前，两组患儿的社会功能缺陷量表（SDSS）评分、自知力与治疗态度问卷（ITAQ）评分比较，差异无统计学意义（P＞0.05）；治疗后，两组的SDSS 评分和ITAQ 评分均低于治疗前，差异有统计学意义（P＜0.05），且辅助干预组的SDSS 评分和ITAQ 评分均低于药物组，差异有统计学意义（P＜0.05）。结论心理社会干预辅助齐拉西酮治疗对于青少年SCH 患者而言能改善其社会功能和自知力状态，有助于提升临床疗效。

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关键词 ：青少年, 精神分裂症, 齐拉西酮, 心理社会干预, 疗效

Abstract：Objective To explore the application effect of psychosocial intervention with adjuvant Zasidone treatment in adolescent schizophrenia (SCH).Methods A total of 88 adolescent schizophrenia SCH patients admitted to the Fourth People′s Hospital of Yingkou City from July 2019 to July 2020 were selected as the study subjects.They were divided into the drug group and the adjuvant intervention group according to random number table method,with 44 cases in each group.The drug group was treated with Zirasidone orally,while the adjuvant intervention group performed a psychosocial intervention on the basis of taking Zirasidone.The clinical efficacy,insight and social function before and after treatment were compared between the two groups.Results The total effective rate of the adjuvant intervention group after treatment was higher than that of the drug group,the difference was statistically significant (P＜0.05).Before treatment,there were no significant differences in the social disability screening schedule (SDSS) score and the insight and treatment attitude questionnaire (ITAQ) scores between the two groups (P＞0.05).After treatment,the scores of SDSS and ITAQ of the two groups were all lower than those before treatment,and the differences were statistically significant (P＜0.05).The scores of SDSS and ITAQ of the adjuvant intervention group after treatment were lower than those in the drug group,and the differences were statistically significant (P＜0.05).Conclusion For the adolescent children with SCH,psychosocial intervention with adjuvant Zirazidone treatment can improve their social function and self-knowledge state,and help to improve the clinical efficacy.

Key words： Adolescent Schizophrenia Ziasidone Psychosocial intervention Efficacy

基金资助:辽宁省营口市科学技术项目（20090304）

引用本文:

宋柳；于素维. 心理社会干预辅助齐拉西酮治疗在青少年精神分裂症中的应用效果[J]. 中国当代医药, 2022, 29(22): 85-87.
SONG Liu1 YU Suwei. Application effect of psychosocial intervention with adjuvant Zirazidone treatment in adolescent schizophrenia. 中国当代医药, 2022, 29(22): 85-87.

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