Objective To explore the application of self-made double fenestration sleeve surgical drape in interventional surgery via distal radial artery and radial artery. Methods A total of 182 patients undergoing distal radial artery and radial artery interventional surgery admitted to Ganzhou Municipal Hospital from December 2019 to June 2021 were selected as the subjects and divided into two groups by random number table method, with 91 cases in each group.The control group was given a conventional surgical towel during the perioperative period, while the observation group was given a self-made double-window sleeve surgical towel.The effect of the patients was evaluated 7 days after the operation, and the visual analogue scale (VAS) score, swelling degree, satisfaction and postoperative life quality were compared between the two groups. Results The VAS scores of the two groups at 1, 3, 5, and 7 days after operation were higher than those before operation, and the differences were statistically significant (P＜0.05).The VAS scores of the observation group at 1 and 3 days after operation were higher than those of the control group, and the differences were statistically significant (P＜0.05).After 7 days of intervention, the degree of swelling in the observation group was less than that of the control group, and the difference was statistically significant (P＜0.05).The satisfactions of intervention method, intervention effect and nurse-patient communication in the observation group were higher than those in the control group after 7 days of intervention, and the differences were statistically significant (P＜0.05).The affective,cognitive function, role function and social function scores were higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The self-made double-window sleeve surgical towel is used in the distal radial artery and radial artery interventional surgery, which can help reduce the pain and swelling of patients, achieve high satisfaction, and reduce the incidence of postoperative complications.It is worthy of promotion and application to improve the quality of life of patients.