Research progress of protective mechanism and application of Magnesium Sulfate on perinatal nervous system
BI Shaohua1 JIANG Liangliang2 LIU Yongqing1 HU Meijun1 LIU Guanghui1
1.Department of Neonatology, Anhui Province Children's Hospital, Anhui Province, Hefei 230000, China;
2.Department of Neurology, Anhui Province Children's Hospital, Anhui Province, Hefei 230000, China
In recent years, the incidence of neonatal brain injury remains high, and major research institutions are actively exploring neuroprotective agents.Magnesium Sulfate, as a non enzymatic antioxidant, has been proved to prevent cerebral palsy before delivery, and Magnesium Sulfate has been included in the neuroprotective guidelines for preterm infants in obstetrics.Magnesium Sulfate has the protective effects of anti-inflammatory, antioxidant and inhibition of apoptosis.Recently, the protective effect of Magnesium Sulfate on the nervous system has been widely concerned at home and abroad, and has become a hot spot in the study of the effect of Magnesium Sulfate.However, there are relatively few studies on Magnesium Sulfate in postpartum.At present, there is no unified conclusion whether postpartum use of Magnesium Sulfate has the same protective effect on nervous system.This paper mainly discusses the protective mechanism of Magnesium Sulfate on neonatal nervous system, reviews the mechanism of action of Magnesium Sulfate,the research of prenatal and postpartum Magnesium Sulfate, and the dosage of Magnesium Sulfate for perinatal newborns, in order to provide reference for clinical and scientific researchers in the research of nervous system protection of perinatal newborns.
毕少华；江亮亮； 刘永青； 胡美君； 刘光辉. 硫酸镁对围生儿神经系统保护机制及其应用的研究进展[J]. 中国当代医药, 2022, 29(23): 39-42.
BI Shaohua1 JIANG Liangliang2 LIU Yongqing1 HU Meijun1 LIU Guanghui1. Research progress of protective mechanism and application of Magnesium Sulfate on perinatal nervous system. 中国当代医药, 2022, 29(23): 39-42.
Larroque B，Ancel PY，Marret S，et al.Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation （the EPIPAGE study）：a longitudinal cohort study[J].Lancet，2008，371（9615）：813-820.
[2]
Garg BD.Antenatal magnesium sulfate is beneficial or harmful in very preterm and extremely preterm neonates：a new insight[J].J Matern Fetal Neonatal Med，2019，32（12）：2084-2090.
[3]
Stockley EL，Ting JY，Kingdom JC，et al.Intrapartum magnesium sulfate is associated with neuroprotection in growthrestricted fetuses[J].Am J Obstet Gynecol，2018，219（6）：606.
[4]
Shepherd E，Salam RA，Middleton P，et al.Antenatal and intrapartum interventions for preventing cerebral palsy: an overview of Cochrane systematic reviews[J].Cochrane Database Syst Rev，2017，8（8）：CD012077.
Fawcett WJ，Haxby EJ，Male DA.Magnesium: physiology and pharmacology[J].Br J Anaesth，1999，83（2）：302-320.
[8]
Chang JJ，Mack WJ，Saver JL，et al.Magnesium：potential roles in neurovascular disease[J].Front Neurol，2014，5：52.
[9]
Zhang LW，Warrington JP.Magnesium Sulfate Prevents Placental Ischemia-Induced Increases in Brain Water Content and Cerebrospinal Fluid Cytokines in Pregnant Rats[J].Front Neurosci，2016，10：561.
[10]
Chollat C，Sentilhes L，Marret S.Fetal Neuroprotection by Magnesium Sulfate：From Translational Research to Clinical Application[J].Front Neurol，2018，9：247.
[11]
Ustün ME，Gürbilek M，Ak A，et al.Effects of magnesium sulfate on tissue lactate and malondialdehyde levels in experimental head trauma[J].Intensive Care Med，2001，27（1）：264-268.
[12]
Koning G，Leverin AL，Nair S，et al.Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection[J].J Cereb Blood Flow Metab，2019，39（6）：1038-1055.
[13]
Bachnas MA，Mose JC，Effendi JS，et al.Influence of antenatal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants[J].J Perinat Med，2014，42（1）：129-134.
[14]
Tang YN，Zhao FL，Ye HM.Expression of caspase-3 mRNA in the hippocampus of seven-day-old hypoxic-ischemic rats and the mechanism of neural protection with magnesium sulfate[J].Zhonghua Er Ke Za Zhi，2003，41（3）：212-214.
[15]
Keepanasseril A，Maurya DK，Manikandan K，et al.Prophylactic magnesium sulphate in prevention of eclampsia in women with severe preeclampsia: randomised controlled trial (PIPES trial) [J].J Obstet Gynaecol，2018，38（3）：305-309.
[16]
Jacobsson B，Saltvedt S，Wikstrom AK，et al.Prediktion, prevention och behandlingsmetoder[J].Lakartidningen，2019，116：FSST.
[17]
Lamhot VB，Khatib N，Ginsberg Y，et al.Magnesium sulfate prevents maternal inflammation-induced impairment of learning ability and memory in rat offspring[J].Am J Obstet Gynecol，2015，213（6）：851，e1-e8.
[18]
Gano D，Ho ML，Partridge JC，et al.Antenatal Exposure to Magnesium Sulfate Is Associated with Reduced Cerebellar Hemorrhage in Preterm Newborns [J].J Pediatr，2016，178：68-74.
[19]
Jung EJ，Byun JM，Kim YN，et al.Antenatal magnesium sulfate for both tocolysis and fetal neuroprotection in premature rupture of the membranes before 32 weeks' gestation[J].J Matern Fetal Neonatal Med，2018，31（11）：1431-1441.
[20]
Jayaram PM，Mohan MK，Farid I，et al.Antenatal magnesium sulfate for fetal neuroprotection：A critical appraisal and systematic review of clinical practice guidelines[J].J Perinat Med，2019，47（3）：262-269.
[21]
Lecuyer M，Rubio M，Chollat C，et al.Experimental and clinical evidence of differential effects of magnesium sulfate on neuroprotection and angiogenesis in the fetal brain[J].Pharmacol Res Perspect，2017，5（4）：e00315.
[22]
García Alonso L，Pumarada Prieto M，González Colmenero E，et al.Prenatal Therapy with Magnesium Sulfate and Its Correlation with Neonatal Serum Magnesium Concentration[J].Am J Perinatol，2018，35（2）：170-176.
[23]
Bachnas MA，Akbar MIA，Dachlan EG，et al.The role of magnesium sulfate （MgSO4） in fetal neuroprotection[J].J Matern Fetal Neonatal Med，2021，34（6）：966-978.
[24]
Ohhashi M，Yoshitomi T，Sumiyoshi K，et al.Magnesium sulphate and perinatal mortality and morbidity in very-lowbirthweight infants born between 24 and 32 weeks of gestation in Japan[J].Eur J Obstet Gynecol Reprod Biol，2016，201：140-145.
[25]
Crowther CA，Middleton PF，Voysey M，et al.Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate：An individual participant data meta-analysis[J].PLoS Med，2017，14（10）：e1002398.
[26]
Singhi S，Johnston M.Recent advances in perinatal neuroprotection[J].F1000Res，2019，8：F1000 Faculty Rev-2031.
[27]
De Silva DA，Synnes AR，von Dadelszen P，et al.MAGnesium sulphate for fetal neuroprotection to prevent Cerebral Palsy (MAG-CP)-implementation of a national guideline in Canada[J].Implement Sci，2018，13（1）：8.
[28]
Jameson RA，Bernstein HB.Magnesium Sulfate and Novel Therapies to Promote Neuroprotection[J].Clin Perinatol，2019，46（2）：187-201.
[29]
Wolf HT，Huusom LD，Henriksen TB，et al.Magnesium sulphate for fetal neuroprotection at imminent risk for preterm delivery：a systematic review with meta-analysis and trial sequential analysis[J].BJOG，2020，127（10）：1180-1188.
[30]
Yates N，Gunn AJ，Bennet L，et al.Preventing Brain Injury in the Preterm Infant-Current Controversies and Potential Therapies[J].Int J Mol Sci，2021，22（4）：1671.
[31]
Bachnas MA，Akbar MIA，Dachlan EG，et al.The role of magnesium sulfate （MgSO4） in fetal neuroprotection[J].J Matern Fetal Neonatal Med，2021，34（6）：966-978.
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