维生素D对多囊卵巢综合征女性生育能力的影响

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摘要目的探讨维生素D 对多囊卵巢综合征（PCOS）女性生育力的影响。方法选择2019年12月至2021年5月于菏泽市立医院妇产科收治的25-羟基维生素D 水平＜20 ng/L 的不孕女性270 例为研究对象，按随机数字表法将其分为维生素D 组与安慰剂组，各135 例。维生素D 组研究对象根据是否患有PCOS 分为A 组（n=75）与B 组（n=60），安慰剂组研究对象根据是否患有PCOS 分为C 组（n=75）与D 组（n=60）。比较各组间的25-羟基维生素D、卵泡刺激素（FSH）、黄体生成素（LH）、LH/FSH、抗苗勒管激素（AMH）、硫酸脱氢表雄酮（DHEAS）及雌二醇水平。比较A 组和C 组研究对象的月经恢复、排卵及妊娠情况。结果 A 组研究对象的25-羟基维生素D、FSH、DHEAS 水平均高于C 组，LH/FSH 低于C 组，差异有统计学意义（P＜0.05）。A 组与C 组研究对象的LH、AMH、雌二醇水平比较，差异无统计学意义（P＞0.05）。B 组研究对象的25-羟基维生素D 水平高于D 组，差异有统计学意义（P＜0.05）。B 组与D 组研究对象的FSH、LH、LH/FSH、AMH、雌二醇、DHEAS 水平比较，差异无统计学意义（P＞0.05）。A 组研究对象的月经恢复率、排卵率均高于C 组，差异有统计学意义（P＜0.05）。A 组与C 组研究对象的妊娠率比较，差异无统计学意义（P＞0.05）。结论维生素D 可能改善PCOS 女性内分泌激素水平状况，对女性生育能力有益。

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关键词 ：维生素D, 多囊卵巢综合征, 抗苗勒管激素, 生育指标

Abstract：Objective To explore the effect of vitamin D on fertility indexes in women with polycystic ovary syndrome(PCOS).Methods A total of 270 infertile women with 25 hydroxyvitamin D level less than 20 ng/L admitted to department of gynecology and obstetrics in Heze Municipal Hospital from December 2019 to May 2021 were selected as the research objects.They were divided into vitamin D group and placebo group according to random number table method,with 135 cases in each group.The subjects in vitamin D group were divided into group A (n=75) and group B (n=60)according to whether they had PCOS.The subjects in the placebo group were divided into group C (n=75) and group D(n=60) according to whether they had PCOS.The levels of 25 hydroxyvitamin D,follicle-stimulating hormone (FSH),luteinizing hormone (LH),LH/FSH,anti-mullerian hormone (AMH),dehydroepiandrosterone sulfate (DHEAS) and estradiol were compared between the two groups.Menstrual recovery,ovulation and pregnancy were compared between group A and group C.Results The levels of 25 hydroxyvitamin D,FSH and DHEAS in group A were higher than those in group C,and the LH/FSH in group A was lower than that in group C,the differences were statistically significant(P＜0.05).There were no significant differences in the levels of LH,AMH and estradiol between group A and group C(P＞0.05).The level of 25 hydroxyvitamin D in group B was higher than that in group D,the difference was statistically significant (P＜0.05).There were no significant differences in the levels of FSH,LH,LH/FSH,AMH,estradiol and DHEAS between group B and group D (P＞0.05).The menstrual recovery rate and ovulation rate in group A were higher than those in group C,the differences were statistically significant (P＜0.05).There was no significant difference in pregnancy rate between group A and group C (P＞0.05).Conclusion Vitamin D may improve the level of endocrine hormone in women with PCOS,and have beneficial effect on fertility index.

Key words： Vitamin D Polycystic ovary syndrome Anti-mullerian hormone Fertility index

通讯作者: 李婕娜，女，博士，研究方向：生殖内分泌。

作者简介: 李燕，女，博士，研究方向：妇科内分泌。

引用本文:

李燕；吴景丽；曹丹；李月；李婕娜. 维生素D对多囊卵巢综合征女性生育能力的影响[J]. 中国当代医药, 2022, 29(22): 46-49.
LI Yan WU Jingli CAO Dan LI Yue LI Jiena. Effect of vitamin D on fertility in women with polycystic ovary syndrome. 中国当代医药, 2022, 29(22): 46-49.

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