Objective To analyze the application effect of psychological rehabilitation in patients with coronary heart disease (CHD) after coronary intervention.Methods A total of 58 patients with CHD who underwent coronary intervention from April 2017 to June 2018 in our hospital were divided into observation group and control group according to the sequence of hospital admission,with 29 cases in each group.Both groups were treated with drugs based on the conventional guideline,and simultaneously controlled the risk factors of CHD by scientific lifestyle,and exercise guidance was conducted according to the patient′ s specific condition.In the observation group,psychological rehabilitation was added.The scores of rehabilitation knowledge,self-care ability,anxiety,and quality of life before and after nursing in both groups were compared.Results In the observation group,the scores of rehabilitation knowledge of CHD and self-care ability were higher than those of the control group,and the differences were statistically significant (P<0.05).1 year after nursing,the anxiety score of the observation group was lower than that of the control group,the quality of life score of the observation group was higher than that of the control group,and the differences were statistically significant (P<0.05).Conclusion Drug therapy,scientific lifestyle intervention and psychological rehabilitation are conducive to the rehabilitation of patients with CHD.