经靶动脉超选灌注碳酸氢钠联合罂粟碱对实体恶性肿瘤化疗栓塞术增效的临床观察

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摘要目的探讨经靶动脉超选灌注碳酸氢钠联合罂粟碱在实体恶性肿瘤化疗栓塞术中的应用效果。方法选取2018年1月～2019年3月于我院行化疗栓塞术治疗的60 例实体恶性肿瘤患者作为研究对象，按照随机数字表法分为研究组与对照组，每组各30 例。研究组行化疗栓塞术+经靶动脉超选灌注碳酸氢钠联合罂粟碱治疗，对照组单纯行化疗栓塞术治疗。比较两组患者的治疗效果、不良反应发生情况，比较两组患者随访6、12 个月后的生存情况以及卡氏（KPS）评分。结果观察组患者的治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。两组患者的白细胞下降、消化道反应、疼痛反应、发热发生率比较，差异无统计学意义（P＞0.05）。两组患者术后12 个月的生存率、KPS 评分与术后6 个月比较，差异无统计学意义（P＞0.05）；观察组患者术后12 个月的生存率高于对照组，术后6、12 个月的KPS 评分均高于对照组，差异有统计学意义（P＜0.05）。结论经靶动脉超选灌注碳酸氢钠联合罂粟碱能够提高实体恶性肿瘤化疗栓塞术的治疗效果，提升远期生存率和KPS 评分，且不会增加不良反应，值得临床推荐。

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关键词 ：实体恶性肿瘤, 碳酸氢钠, 罂粟碱, 化疗栓塞术

Abstract：Objective To investigate the application effect of superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery on chemoembolization of solid malignant tumor. Methods A total of 60 patients with solid malignant tumor treated by chemoembolization in our hospital from January 2018 to March 2019 were selected as the research subjects and divided into the study group and the control group according to the random number table method, with 30 cases in each group. The study group was treated by chemoembolization+target artery superselective infusion of Sodium Bicarbonate combined with Papaverine, while the control group was treated by chemoembolization alone. The therapeutic effect, side effects of the two groups were compared. The survival and Karnofsky(KPS) scores after 6 and 12 months of follow-up of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There were no statistically significant differences in the incidence of leucopenia, gastrointestinal reaction, pain reaction and fever between the two groups (P＞0.05). There were no statistically significant differences in survival rate and KPS scores between the two groups after 6 and 12 months of follow-up (P＞0.05). The survival rate of the observation group after 12 months of follow-up was higher than that of the control group, and the KPS scores of the observation group after 6 and 12 months of follow-up were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery can improve the therapeutic effect of chemoembolization for solid malignant tumors, improve the long-term survival rate and KPS score, and will not increase the side effects, which is worthy of clinical recommendation.

Key words： Solid malignant tumor Sodium Bicarbonate Papaverine Chemoembolization

收稿日期: 2020-04-07

引用本文:

周全；吴斌；胡爱萍. 经靶动脉超选灌注碳酸氢钠联合罂粟碱对实体恶性肿瘤化疗栓塞术增效的临床观察[J]. 中国当代医药, 2020, 27(29): 87-90.
ZHOU Quan1 WU Bin1 HU Ai-ping2. Clinical observation on the effect of superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery on chemoembolization of solid malignant tumor. 中国当代医药, 2020, 27(29): 87-90.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2020/V27/I29/87

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