Abstract: With the reform of medical model in China,people′s requirements for medical technology,service quality and diagnosis and treatment environment are also increasing year by year,which brings greater challenges to the development of medical career.However,due to the lack of perfect management ability in some hospitals,the logistics cost has increased significantly.With the innovation of hospital logistics cost management mode,the traditional extensive management mode has also changed to the standardized and refined mode gradually,which saves a lot of human,material and financial resources for the hospital.The use of refined management in hospital logistics management is in line with the needs of the current era.It is an effective measure to solve the contradiction between people′s growing medical and health needs and outdated management methods.Only by introducing the concept of refined management into the logistics management of hospital,can the current backward management methods be changed,to realize the unity of management and service,and reduce the hospital Logistics management cost.This paper analyzes the problems in the refined management of hospital logistics cost in detail,and analyzes the measures to solve the problems in combination with the actual situation of the current hospital logistics management,so as to provide reference for the application of refined management in the hospital logistics cost management.