Abstract: Objective To compare the influence of ultrasound combined with nerve stimulator guidance and ultrasound guidance on the effect of axillary brachial plexus block.Methods A total of 100 patients who intended to undergo forearm and hand surgery in our hospital from January to April 2018 were selected as the research objects,and the patients were divided into ultrasound combined with nerve stimulator group (group NU) and control group (group U) by the random number table method,50 cases in each group.The group NU was guided by ultrasound combined with nerve stimulator,and the group U was only guided by ultrasound.The anesthesia effect,nerve block onset time,operation and incidence of complications between the two groups were observed.Results The success rate of nerve block anesthesia in the group NU (100.00%) was higher than that in group U (72.00%),the difference was statistically significant (P<0.05).The sensory block onset time of musculocutaneous nerve,radial nerve,median nerve and ulnar nerve in the group NU was shorter than that in the group U,and the difference was statistically significant (P<0.05).The operation time in the group NU was shorter than that in the group U,and the duration of nerve block was longer than that in the group U,with statistically significant differences (P<0.05).The total incidence of complications in the group NU (4.00%) was lower than that in the group U (26.00%),and the difference was statistically significant (P<0.05).Conclusion Ultrasound combined with nerve stimulator to guide axillary brachial plexus block has a higher success rate,shorter onset time,operation time,longer duration,and fewer complications,indicating that ultrasound combined with nerve stimulator to guide axillary brachial plexus block is effective and safe.