摘要目的 观察铜绿假单胞菌注射液联合顺铂结合局部热疗治疗癌性腹水的临床效果。方法 选取北京燕化医院2016年6月～2019年6月收治的58例癌性腹水患者作为研究对象，按照随机数字表法分为A组 （19例）、B组（19例）、C组（20例）。充分引流腹水后，A组予以顺铂局部灌注，B组予以顺铂局部灌注1 h 后行局部热疗，C组予以顺铂局部灌注1 h 后行局部热疗，3 d 后局部灌注铜绿假单胞菌注射液。间隔7 d，2 周为1个疗程，共进行2个疗程，1个月后复查评定腹水减少情况、功能状态评分（KPS）及不良反应。结果 C组的腹水减少治疗总有效率高于A组，差异有统计学意义（P<0.05）。C组治疗后的KPS评分高于A组，差异有统计学意义（P<0.05）。C组的KPS评分提高率高于A组，差异有统计学意义（P<0.05）。A组、B组的不良反应总发生率与C组比较，差异无统计学意义（P>0.05）；A组、B组的不良反应总发生率比较，差异无统计学意义（P>0.05）。结论 铜绿假单胞菌注射液联合顺铂结合局部热疗治疗癌性腹水的临床效果良好，可改善患者功能状态。
Abstract：Objective To observe the clinical efficacy of Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia in the treatment of cancerous ascites.Methods A total of 58 patients with cancerous ascites admitted to Beijing Yanhua Hospital from June 2016 to June 2019 were selected as the research objects,and they were divided into group A (19 cases),group B (19 cases) and group C (20 cases) according to the random number table method.After adequate drainage of ascites,group A was treated with Cisplatin,group B was received local hyperthermia after one hour of Cisplatin perfusion,while group C was treated with local hyperthermia one hour after infusion of Cisplatin,and was perfused with Pseudomonas Aeruginosa Injection three days later.Two weeks were a treatment cycle,totally two cycles after apart seven days.The ascites reduction,functional state score (KPS) and adverse reactions were assessed one month later..Results The total effective rate of ascites reduction in group C was higher than that in group A,the difference was statistically significant (P<0.05).The KPS score of group C after treatment was higher than that of group A,the difference was statistically significant (P<0.05).The improvement rate of KPS in group C was higher than that in group A,the difference was statistically significant (P<0.05).There were no significant difference in the total incidence of adverse reactions between group A and group B compared with group C (P>0.05),and there was no significant difference in the total incidence of adverse reactions between group A and group B (P>0.05).Conclusion Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia has a good clinical effect in the treatment of cancerous ascites,and it can improve the functional status of patients.
王翠红；石文魁；王毛毛；范宇飞. 铜绿假单胞菌注射液联合顺铂结合局部热疗治疗癌性腹水的临床效果[J]. 中国当代医药, 2020, 27(36): 94-97.
WANG Cui-hong； SHI Wen-kui；WANG Mao-mao； FAN Yu-fei. Clinical effect of Pseudomonas Aeruginosa Injection combined with Cisplatin and local hyperthermia in the treatment of cancerous ascites. 中国当代医药, 2020, 27(36): 94-97.
Bekes I，Friedl TW，Kohler T，et al.Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion，thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?[J].Mol Cancer，2016，15：13.
[3]
Liu ZB，Hou YF，Zhu J，et al.Inhibition of EGFR pathway signaling and the etastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannosedependent manner[J].Oncogene，2010，29（20）：2996-3009.
Chen WC，Qiu JT，Lai CH，et al.Outcomes and prognoses of patients with ovarian cancer using bevacizumab：6-year experience in a tertiary care hospital of northern Taiwan[J].PLoS One，2017，12（5）：e0175703.
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