Abstract:Objective To understand the differences of the diseased locations in adults with unilateral or bilateral upper urinary tract stones.Methods From January to October 2019,447 adult outpatients diagnosed with upper urinary tract stones in Panyu Hospital of Chinese Medicine were enrolled as the study sample.The questionnaire was used to record patients′ daily eating habits and calculus location..Results The prevalence of bilateral upper urinary tract stones in males (44.7%) was higher than that in females (28.8%),the difference is statistically significant (P<0.05); the prevalence of bilateral upper urinary tract stones in males was higher than left or right side stones (SR=3.5,|SR|>3),and the difference is statistically significant difference (P<0.05); in the unilateral upper urinary tract stones cases in both sexes,the left side was more common,but there was no significant difference (P>0.05); the risk of bilateral upper urinary tract stones in male was significantly higher than female (RR=1.555,95%CI=1.207-2.002,P<0.05).Conclusion The prevalence of unilateral upper urinary tract stones in adult patients is higher than bilateral; the left side stones are more common than the right side in the unilateral upper urinary tract stones patients; the prevalence of bilateral calculi in males is higher than females.It suggests that gender differences could be one of the factors that affect the formation and progression of kidney stones.
黄效维. 上尿路结石成人患者单双侧发病部位的对比研究[J]. 中国当代医药, 2020, 27(36): 80-83.
HUANG Xiao-wei. A comparative study of the diseased locations of unilateral and bilateral upper urinary tract stones in adult patients. 中国当代医药, 2020, 27(36): 80-83.
Gupta K,Gill GS,Mahajan R.Possible role of elevated serum testosterone in pathogenesis of renal stone formation[J].Int J Appl Basic Med Res,2016,6(4):241-244.
[7]
Zhu W,Zhao Z,Chou F,et al.Loss of the androgen receptor suppresses intrarenal calcium oxalate crystals deposition via altering macrophage recruitment/M2 polarization with change of the miR-185-5p/CSF-1 signals[J].Cell Death Dis,2019,10(4):275-294.
[8]
Peng Y,Fang Z,Liu M,et al.Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway[J].J Transl Med,2019,17(1):62-75.
[9]
Zhu W,Zhao Z,Chou FJ,et al.The protective roles of estrogen receptor β in renal calcium oxalate crystal formation via reducing the liver oxalate biosynthesis and renal oxidative stress-mediated cell injury[J].Oxid Med Cell Longev,2019,2019:5305014.
Liu Y,Chen Y,Liao B,et al.Epidemiology of urolithiasis in Asia[J].Asian J Urol,2018,5(4):205-214.
[13]
Knoedler JJ,Krambeck AE,Astorne W,et al.Sex steroid hormone levels may not explain gender differences in development of nephrolithiasis[J].Endourol,2015,29(12):1341-1345.
[14]
Goldfarb DS,Avery AR,Beara-Lasic L,et al.A twin study of genetic influences on nephrolithiasis in women and nen[J].Kidney Int Rep,2018,4(4):535-540.