Abstract：Objective To explore and analyze the application effect and clinical significance of serum S100B protein in hypoxic-ischemic encephalopathy (HIE) in neonates and provide clinical basis for the assessment of HIE condition and prognosis.Methods A total of 150 HIE children admitted to the neonatology department of our hospital from January to December 2017 were selected as the experimental group.The experimental group was divided into the severe HIE group (40 cases),the moderate HIE group (50 cases) and the mild HIE group (60 cases) according to the severity of the condition.A total of 60 normal neonates were selected as the control group.Serum samples of different groups were collected on the 1st,3rd and 7th days after birth,and serum samples of the control group were collected on the 1st day after birth.Serum S100B protein concentration was measured by enzyme-linked immunosorbent assay (ELISA),and the difference of serum S100B protein concentration between the experimental group and the control group was compared.According to the assessment results of Gesell development scale,all the HIE children were divided into the group with sequelae (41 cases) and the group without sequelae (109 cases),and the serum S100B protein concentrations of the two groups on 1st,3rd and 7th days were compared respectively.Results The serum S100B protein concentration of experimental group on the 1st day after birth was higher than that of the control group,and the difference was statistically significant (P<0.05).The serum S100B protein concentration of experimental group on the 3rd and 7th days after birth were higher than those on the 1st day,and the differences were statistically significant (P<0.05).The serum S100B protein concentration of severe HIE group on the 1st,3rd and 7th days after birth were higher than those of the moderate HIE group and the mild HIE group,and the differences were statistically significant (P<0.05).The serum S100B protein concentration of moderate HIE group on the 1st,3rd and 7th days after birth were higher than those of the mild HIE group,and the differences were statistically significant (P<0.05).The serum S100B protein concentration of group with sequelae on the 1st,3rd and 7th days after birth were higher than those of the group without sequelae,and the differences were statistically significance (P<0.01).Conclusion Serum S100B protein concentration in HIE children is higher than that in normal neonates,and the serum S100B protein concentration of children with sequelae is higher than that of children without sequelae.Therefore,detection of serum S100B protein concentration is conducive to the early diagnosis and prognosis evaluation of neonatal HIE disease.
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