Abstract:Objective To evaluate the clinical effect of Allicin in the treatment of long-term bedridden senile pneumonia.Methods A prospective randomized control study was conducted.Totally 105 long-term bedridden senile pneumonia patients treated in Hefei Binhu Hospital from October 2018 to February 2020 were selected,and were divided into the control groups (n=60) and the treatment group (n=45) with simple randomization.The control group was treated with pneumonic standard treatment,and the treatment group was given extra Allicin for 14 d on the basis of the therapy of the control group.Distribution of pathogenic bacteria,inflammation indicators,therapeutic efficacy and durations of antibiotics were compared and analyzed between the two groups.Allicin adverse reactions and its incidence rate were recorded throughout the course..Results ①The most common pathogens were Pseudomonas aeruginosa (36.2%),Klebsiella pneumonia (23.8%),Escherichia coli (7.6%),Acinetobacter baumannii (4.8%) and Staphylococcus aureus (4.8%)in long-term bedridden senile pneumonic patients.②The levels of white blood cell (WBC) and C-reactive protein(CRP) of the treatment group were lower than those in the control group after therapy,the differences were statistically significant (P<0.01).③The rate of therapeutic effect of 97.8% in the treatment group was higher than 76.7% of the control group,the difference was statistically significant (P<0.05).④The antibiotics using time was shorter than that in the control group,the difference was statistically significant (P<0.01).⑤The incidence rate of adverse reactions in the treatment group was 4.44%,one was diarrhea,and the other was skin rash.Conclusion Additional Allicin treatment in long-term bedridden senile pneumonic patients can significantly shorten the use of antibiotics and improve the curative effection on the basis of treatment with antibiotic,and it could be safe with low incidence of adverse reactions when used in clinic.
金吴娟. 大蒜素在长期卧床老年肺炎患者治疗中的效果分析[J]. 中国当代医药, 2020, 27(36): 52-55.
JIN Wu-juan. Effect analvsis of Allicin in the treatment of long-term bedridden senile pneumonia. 中国当代医药, 2020, 27(36): 52-55.