Abstract：Objective To explore the effect of nasal hormone drugs combined with leukotriene receptor antagonists in the treatment of allergic rhinitis (AR) and the influence on patients′ nasal secretion eosinophils (EOS),serum immunoglobulin E (IgE),soluble ST2 (sST2) and related cytokines.Methods A total of 120 AR patients from January 2016 to May 2018 admitted to Changzhou Maternal and Child Health Hospital were selected as the research objects and divided into the combined group and the control group by the randomized block design,with 60 cases in each group.Both groups were given Mometasone Furoate Nasal Spray for treatment,the combined group was treated with Montelukast Sodium Chewable Tablets at the same time.The scores of nasal congestion symptom,sneezing symptom,nasal itching symptom,runny nose symptom,nasal EOS positive rate,serum IgE,interleukin-6 (IL-6),and interleukin-8 (IL-8) before and after treatment and clinical efficacy were compared between the two groups.Results After 4 weeks of treatment,the scores of nasal congestion symptom,sneezing symptom,nasal itching symptom and runny nose symptom in the combined group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After 4 weeks of treatment,the nasal EOS positive rate,serum IgE,IL-6 and IL-8 levels in the combined group were lower than those in the control gr oup,and the differences were statistically significant (P＜0.05).The clinical efficacy of the combined group was better than that of the control group,and the di fference was statistically significant(P＜0.05).Conclusion The effect of Mometasone Furoate Nasal Spray combined with Mont elukast Sodium Chewable Tablets is better than that of mometasone furoate nasal spray in the treatment of AR patients.
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