Abstract:Objective To explore the relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting undergoing breast surgery.Methods From December 2016 to January 2019,240 female patients who received breast surgery with general anesthesia in Fujian Medical University Union Hospital were selected as the subjects.Age,body mass index (BMI),history of motion sickness,history of postoperative nausea and vomiting,duration of anesthesia and occurrence of postoperative nausea and postoperative vomiting in early and later period (within first 6 hours and within 6 to 24 hours after surgery,respectively) were recorded.Improved multiple ligase detection reaction(iMLDR) was used for genotyping and relationship between ABCB1 rs2032582 gene polymorphism and postoperative nausea and vomiting was analyzed with logistic regression model.Results Patients carrying CT genotype had a 4.674 times greater risk of postoperative nausea than those carrying CC genotype in later period,CT genotype was a risk factor for postoperative nausea in later period (β=1.542,OR=4.674,95%CI=1.138-19.202,P<0.05).Conclusion ABCB1 rs2032582 gene polymorphism had an association with postoperative nausea in later period,which may be one of important factors affecting female genetic susceptibility to postoperative nausea and vomiting undergoing breast surgery with general anesthesia.
Aroke EN,Hicks TL.Pharmacogenetics of postoperative nausea and vomiting[J].J Perianesth Nurs,2019,34(6):1088-1105.
[2]
Son J,Yoon H.Factors affecting postoperative nausea and vomiting in surgical patients[J].J Perianesth Nurs,2018,33(4):461-470.
[3]
Habib AS,Keifer JC,Borel CO,et al.A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy[J].Anesth Analg,2011,112(4):813-818.
[4]
Tateosian VS,Champagne K,Gan TJ.What is new in the battle against postoperative nausea and vomiting?[J].Best Pract Res Clin Anaesthesiol,2018,32(2):137-148.
[5]
Aydin A,Kac,maz M,Boyaci A.Comparison of ondansetron,tropisetron,and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery[J].Curr Ther Res Clin Exp,2019,91:17-21.
[6]
Lopez-Morales P,Flores-Funes D,Sanchez-Migallon EG,et al.Genetic factors associated with postoperative nausea and vomiting:a systematic review[J].J Gastrointest Surg,2018,22(9):1645-1651.
[7]
Campos GO,Martins MJ,Jesus MN,et al.Palonosetron versus ondansetron for prevention of nausea and vomiting after total abdominal hysterectomy under spinal anesthesia with intrathecal morphine:a double-blind,randomized controlled trial[J].BMC Anesthesiol,2019,19(1):159-164.
[8]
Italian Group for Antiemetic Research.Double-blind,dosefinding study of four intravenous doses of dexamethasone in the prevention of cisplatin-induced acute emesis[J].J Clin Oncol,1998,16(9):2937-2942.
Viktoria Z,Thomas W,Markus K,et al.Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET[J].J Cereb Blood Flow Metab,2020,40(1):150-162.
[11]
Trexler AW,Knudsen GA,Nicklisch S,et al.2,4,6-Tribromophenol exposure decreases P-glycoprotein transport at the blood-brain barrier[J].Toxicol Sci,2019,171(2):463-472.
[12]
Salaroglio IC,Abate C,Rolando B,et al.Validation of thiosemicarbazone compounds as P-glycoprotein inhibitors in human primary brain-blood barrier and g lioblastoma stem cells[J].Mol Pharm,2019,16(8):3361-3373.
Gibbs ME,Wilt LA,Ledwitch KV,et al.A conformationally gated model of methadone and loperamide transport by Pglycoprotein[J].J Pharm Sci,2018,107(7):1937-1947.
[15]
Bilgen S,Kizilcik N,Haliloglu M,et al.Effect of the dexamethasone-ondansetron combination versus dexamethasone-aprepitant combination to prevent postoperative nausea and vomiting[J].Turk J Anaesthesiol Reanim,2018,46(5):373-380.
[16]
Kovac AL.Updates in the management of postoperative nausea and vomiting[J].Adv Anesth,2018,36(1):81-97.
Yu C,Yuan M,Yang H,et al.P-glycoprotein on blood-brain barrier plays a vital role in fentanyl brain exposure and respiratory toxicity in rats[J].Toxicol Sci,2018,164(1):353-362.
[19]
Callaghan R,Riordan JR.Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells[J].J Biol Chem,1993,268(21):16059-16064.
[20]
Mercer SL,Coop A.Opioid analgesics and P-glycoprotein efflux transporters:a potential systems-level contribution to analgesic tolerance[J].Curr Top Med Chem,2011,11(9):1157-1164.
Owen A,Goldring C,Morgan P,et al.Relationship between the C3435T and G2677T(A)polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver[J].Br J Clin Pharmacol,2005,59(3):365-370.
[23]
Gong XD,Wang JY,Liu F,et al.Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese patients with cancer pain[J].Asian Pac J Cancer Prev,2013,14(5):2937-2943.