奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者的效果比较

摘要
图/表
参考文献(16)
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者的效果。方法选取吉安市中心人民医院2018年1月～2019年6月收治的94例颅脑损伤并发应激性消化道出血患者作为研究对象，按照随机数字表法分为研究组（47例）和对照组（47例），对照组采用泮托拉唑治疗方法，研究组采用奥美拉唑与泮托拉唑治疗方法。比较两组的治疗总有效率、血清胃泌素、血红蛋白、止血时间和输血量。结果研究组总有效率高于对照组，差异有统计学意义（P＜0.05）；两组治疗前胃泌素和血红蛋白指标比较，差异无统计学意义（P＞0.05）；治疗后，两组的胃泌素低于治疗前，血红蛋白高于治疗前，且研究组的胃泌素低于对照组，血红蛋白高于对照组，差异有统计学意义（P＜0.05）。研究组止血时间短于对照组，差异有统计学意义（P＜0.05）；研究组输血量少于对照组，差异有统计学意义（P＜0.05）。结论应用奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者效果显著，可有效防止应激性消化道出血，降低胃泌素水平，还可以缩短止血时间，减少输血量，有利于患者尽快康复，值得大力推广。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	邓启亮
	邓永胜
	邹文雄
	王李妮
	陈伟
	彭庆明
	刘娟妹

关键词 ：奥美拉唑, 颅脑损伤, 应激性消化道出血, 胃泌素

Abstract：Objective To investigate the effect between Omeprazole and Pantoprazole in the treatment of patients with craniocerebral injury complicated with stress gastrointestinal bleeding.Methods A total of 94 patients with craniocerebral injury and stress gastrointestinal bleeding admitted to Ji′an Central People′s Hospital from January 2018 to June 2019 were selected as the research objects,according to random number table method,they were divided into research group (47 cases) and control group (47 cases).The control group was treated with Pantoprazole and the study group was treated with Omeprazole and Pantoprazole.The therapeutic effect,serum gastrin,hemoglobin,hemostasis time and blood transfusion volume of the two groups were compared.Results The curative effect of the study group was higher than that of the control group,the difference was statistically significant (P＜0.05).There were no statistically significant differences between the two groups in gastrin and hemoglobin before treatment(P＞0.05).After treatment,the gastrin of the two groups was lower than that before treatment,the hemoglobin was higher than that before treatment,and the gastrin of the study group was lower than that of the control group,the hemoglobin was higher than that of the control group,the differences were statistically significant (P＜0.05).The hemostasis time of the study group was shorter than that of the control group,and the difference was statistically significant (P＜0.05).The blood transfusion volume of the study group was less than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion Omeprazole and Pantoprazole have a significant therapeutic effect on patients with craniocerebral injury complicated with stress gastrointestinal bleeding.It can not only reduce serum gastrin level and improve hemoglobin index,but also shorten the time of hemostasis and reduce the amount of blood transfusion,which is conducive to the recovery of patients as soon as possible.Therefore,it is worth promoting vigorously.

Key words： Omeprazole Craniocerebral injury Stress gastrointestinal bleeding Gastrin

基金资助:江西省卫健委科技计划（指导性计划）项目(2018 7305)

作者简介: 邓启亮（1982-），男，博士，主治医师，研究方向：消化病学及消化内镜

引用本文:

邓启亮；邓永胜；邹文雄；王李妮；陈伟；彭庆明；刘娟妹. 奥美拉唑与泮托拉唑治疗颅脑损伤并发应激性消化道出血患者的效果比较[J]. 中国当代医药, 2020, 27(35): 40-43.
DENG Qi-liang； DENG Yong-sheng； ZOU Wen-xiong ；WANG Li-ni； CHEN-Wei ；PENG Qing-ming； LIU Juan-mei. Comparison of the effect between Omeprazole and Pantoprazole in the treatment of patients with craniocerebral injury and stress gastrointestinal bleeding. 中国当代医药, 2020, 27(35): 40-43.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2020/V27/I35/40

[1]	王卫国.大剂量奥美拉唑治疗溃疡性上消化道出血效果及对血红蛋白水平的影响[J].中外医学研究，2019，11（8）：21-22.
[2]	王雪峰，谢晨，麻旭东，等.奥维加对比泮托拉唑预防重型颅脑损伤并发应激性溃疡的疗效评估[J].健康之路，2018，16（1）：22.
[4]	王代梅.奥美拉唑治疗脑血管病并发应激性溃疡上消化道出血60例临床分析[J].系统医学，2019，4（12）：13-15.
[5]	汪颖，王迪芬，付江泉，等.不同肠内营养制剂应用于重型颅脑损伤患者的临床观察[J].中华危重病急救医学，2019，31（2）：209-213.
[3]	Chen F，Xu C，Zhang C.Effect of indwelling nasointestinal tube for enteral nutrition support in patients with severe craniocerebral trauma undergoing mechanical ventilation[J].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue，2018，30（1）：57.
[6]	Lin WC，Chu CH.A rare cause of gastrointestinal hemorrhage[J].Ann Ital Chir，2018，16（1）：158-159.
[7]	王艳芳，张丽.奥美拉唑和泮托拉唑治疗上消化道出血的疗效及安全性比较[J].中国实用医刊，2018，45（22）：94.
[8]	肖乐，崔焱.个性化舒适护理在急性脑卒中并发上消化道出血患者中的应用研究[J].齐齐哈尔医学院学报，2019，40（14）：1840-1841.
[9]	Fan D，Wu S，Ye S.Random placenta margin incision for control hemorrhage during cesarean delivery complicated by complete placenta previa：a prospective cohort study[J].J Matern Fetal Neonatal Med，2018，32（4）：1-11.
[10]	吕宝琴.泮托拉唑治疗消化性溃疡合并上消化道出血的效果研究[J].当代医药论丛，2019，15（9）：127-128.
[11]	孙艳，马铁柱，陈翀，等.合募配穴针刺治疗颅脑创伤后应激性胃黏膜损伤的疗效观察[J].中华危重病急救医学，2018，30（6）：564-568.
[12]	Alvaro Martínez-Alcalá，Klaus Mpagenumber_ebook=49,pagenumber_book=43nkempagenumber_ebook=49,pagenumber_book=43ller.Emerging Endoscopic Treatments for Nonvariceal Upper Gastrointestinal Hemorrhage[J].Gastrointest Endosc Clin N Am，2018，28（3）：307.
[13]	刘菁菁，刘文宏，贺茂林.急性脑梗死合并应激性上消化道出血的危险因素[J].中国神经精神疾病杂志，2019，45（3）：11-14.
[14]	卜晓芬，李骏，朱虹.泮托拉唑、奥曲肽、血凝酶联用治疗老年急性上消化道出血的疗效及对血清D-二聚体、ALB、AST水平的影响[J].中国老年学杂志，2019，39（7）：78-80.
[15]	颜小丹，周金虎.奥曲肽联合泮托拉唑治疗老年消化性溃疡合并上消化道出血的疗效及对凝血功能和炎症因子的影响[J].中国老年学杂志，2018，38（2）：2902-2904.
[16]	崔钰，任天舒，侯冠昕，等.泮托拉唑预防急性脑梗死并发应激性溃疡的有效性和安全性分析[J].中国医院药学杂志，2018，38（1）：75-77.