子宫内膜息肉发病及恶变的临床因素分析

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摘要目的研究子宫内膜息肉（EP）发病的原因及出现恶变的影响因素，为该疾病的预防以及治疗给予数据支持。方法选取2018年1月至2020年12月就诊于北京市大兴区中西医结合医院妇科的243 例彩超提示可疑EP患者作为研究对象，所有患者均进行宫腔镜检查，对患者的临床信息进行详细记录，包括症状体征、年龄、体重指数（BMI）、宫内节育器放置史、孕产次、宫颈息肉、子宫肌瘤、子宫腺肌病、高血压、糖尿病等临床资料，依照病理数据将其分成对照组（24 例）、EP 良性组（197 例）和EP 恶性组（22 例），采用单因素以及多因素logistic 回归分析EP 发病及恶变的危险因素。结果单因素分析结果显示，EP 良性组与对照组的宫内节育器、宫颈息肉、子宫肌瘤、肥胖以及糖尿病发生率比较，差异有统计学意义（P＜0.05）；EP 良性组与EP 恶性组的月经淋漓不净、肥胖以及高血压发生率比较，差异有统计学意义（P＜0.05）。多因素logistic 回归分析结果显示，宫颈息肉（β=2.19，OR=3.47，95%CI=1.552～7.181）、子宫肌瘤（β=1.83，OR=2.30，95%CI=0.691～7.660）、肥胖（β=1.91，OR=2.02，95%CI=0.082～10.157）是EP 发病的危险因素（P＜0.05）；月经淋漓不净（β=1.53，OR=2.39，95%CI=1.240～8.871）、肥胖（β=2.96，OR=2.45，95%CI=1.552～7.088）是EP 恶变的危险因素（P＜0.05）。结论宫颈息肉、子宫肌瘤、肥胖是EP 发病的独立危险因素；月经淋漓不净、肥胖是EP 恶变的独立危险因素。

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	王丽丽
	杨珊珊
	薛杰
	郑玮

关键词 ：子宫内膜息肉, 发病, 恶变, 临床因素, 单因素分析

Abstract：Objective To investigate the clinical factors of endometrial polyps (EP) and canceration,to provide evidence for clinical prevention and treatment.Methods From January 2018 to December 2020,the ultrasound examination in Integrated Traditional Chinese and Western Medicine Hospital of Daxing District showed 243 patients with suspected EP were selected as the research objects.All patients underwent hysteroscopy.The clinical symptoms,signs,age,body mass index (BMI),intrauterine device,gravidity and parity,cervical polyp,hysteromyoma,adenomyosis,diabetes,hypertension of the patients were recorded.According to pathological results,they were divided into control group (24 cases),benign EP group (197 cases) and malignant EP group (22 cases).The single-factor,multi-factor logistic regression analysis were used to investigate the risk factors of EP.Results Univariate analysis results showed that the differences in intrauterine device,cervical polyp,hysteromyoma,obesity,diabetes between benign EP group and control group were statistically significant (P＜0.05).The differences in hysteromyoma,obesity and menstruation is not clean between benign EP group and malignant EP group were statistically significant (P＜0.05).Multivariate logistic regression analysis showed that cervical polyp (β=2.19, OR=3.47,95%CI=1.552-7.181),hysteromyoma (β=1.83, OR=2.30,95%CI=0.691-7.660) and obesity (β=1.91, OR=2.02,95%CI=0.082-10.157) were risk factors of the onset of EP(P＜0.05).Obesity (β=2.96, OR=2.45,95%CI=1.552-7.088) and menstruation is not clean (β=1.53, OR=2.39,95%CI=1.240-8.871) were risk factors of the malignant transformation of EP (P＜0.05).Conclusion Cervical polyp,hysteromyoma and obesity are independent factors of EP.Obesity and menstruation is not clean are independent factors of EP malignant transformation.

Key words： Endometrial polyps Etiology Malignant transformation Clinical factors Univariate analysis

基金资助:王丽丽（1983-），女，河北定州人，硕士，主要从事妇产科临床工作。

引用本文:

王丽丽；杨珊珊；薛杰；郑玮. 子宫内膜息肉发病及恶变的临床因素分析[J]. 中国当代医药, 2022, 29(17): 116-118.
WANG Lili； YANG Shanshan； XUE Jie ；ZHENG Wei. Analysis of clinical factors for endometrial polyps and canceration. 中国当代医药, 2022, 29(17): 116-118.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I17/116

[1]	Sasaki LMP，Andrade KRC，Figueiredo ACMG，et al.Factors associated with malignancy in hysteroscopically resected endometrial polyps：a systematic review and meta-analysis[J].J Minim Invasive Gynecol，2018，25（5）：777-785.
[2]	姜伶俐，吴方跃.子宫内膜息肉的临床研究进展[J].中国当代医药，2018，25（28）：29-31，35.
[3]	Ghoubara A，Sundar S，Ewies AAA.Predictors of malignancy in endometrial polyps：study of 421 women with postmenopausal bleeding[J].Climacteric，2017，21（1）：82-87.
[4]	Gokmen Karasu AF，Sonmez FC，Aydin S，et al.Survivin Expresion in simple endometrial polyps and Tamoxifen-associated endometrial polyps[J].Int J Gynecol Pathol，2018，37（1）：27-31.
[5]	Serhat E，Cogendez E，Selcuk S，et al.Is there a relationship between endometrial polyps and obesity，diabetes mellitus，hypertension?[J].Arch Gynecol Obstet，2014，290 （5）：937-941.
[6]	Chowdary P，Maher P，Ma T，et al.The role of the mirena intrauterine device in the management of endometrial polyps：a pilot study[J].J Minim Invasive Gynecol，2019，26（7）：1297-1302.
[7]	刘晓玉，沈媛.子宫内膜息肉的发病机制[J].广东医学，2020，41（17）：1824-1826.
[8]	陈艺华，修晓新.绝经后女性子宫内膜息肉发生癌前病变及癌的危险因素分析[J].大连医科大学学报，2016，38（2）：151-154，158.
[9]	Pergialiotis V，Prodromidou A，Siotos C，et al.Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps：a meta-analysis of observational studies[J].Menopause，2016，23（6）：691-697.
[10]	邵超，梁婧，龚文婧.宫腔镜子宫内膜息肉切除术后预防复发的Meta 分析[J].医学综述，2020，26（12）：2464-2469.
[13]	郑璐，李权.凝血相关疾病所致异常子宫出血的治疗进展[J].海南医学，2019，30（3）：380-383.
[14]	孙小媛，张雪刚.子宫内膜息肉发病及癌变的危险因素分析[J].海南医学，2019，30（8）：68-71.
[11]	Luerti M，Vitagliano A，Di Spiezio Sardo A，et al.Effectiveness of hysteroscopic techniques for endometrial polyp removal：the Italian multicenter trial[J].J Minim Invasive Gynecol，2019，26（6）：1169-1176.
[12]	Ozelci R，Dilbaz B，Akp1nar F，et al.The significance of sonographically thickened endometrium in asymptomatic postmenopausal women[J].Obstet Gynecol Sci，2019，62（4）：273-279.
[15]	张月华，王璐祎，张色华.影响子宫内膜不典型增生诊断及病理升级的相关因素分析[J].中国当代医药，2020，27（3）：32-34.