Abstract：Objective To explore the relationship between Mycoplasma pneumoniae infection and airway hyperresponsiveness. Methods A total of 60 children with lower respiratory tract infection diagnosed as Mycoplasma pneumoniae infection in our hospital from October 2019 to January 2020 were selected into the observation group, and 60 children with lower respiratory tract infection diagnosed as non Mycoplasma pneumoniae infection in the same period were selected into the control group. The lung function indexes (forced vital capacity [FVC], forced expiratory volume in the first second [FEV1], FEV1/FVC, peak expiratory flow rate [PEF%], maximum voluntary ventilation [MVV], maximum mid-term expiratory flow [MMEF 25-75]) and serum IgE test results of children in the two groups were compared. According to the difference of serum specific IgG antibody titers, the observation group was divided into high titer group and low titer group, and the lung function indexes and serum IgE test results of children with different antibody titers were compared. Results The results of FVC, FEV1, FEV1/FVC, PEF%, MVV and MMEF 25-75 in the observation group were lower than those in the control group, and the serum IgE test results was higher than that in the control group, the differences were statistically significant (P＜0.05). The results of FVC, FEV1, FEV1/FVC, PEF%, MVV and MMEF 25-75 in the high titer group were lower than those in the low titer group, and the serum IgE test results was higher than that in the low titer group, the differences were statistically significant (P＜0.05). Conclusion Mycoplasma pneumoniae infection can reduce the lung function of children with lower respiratory tract infection and cause airway hyperresponsiveness, which needs to be diagnosed and treated as soon as possible.
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