Correlation between urine liver-type fatty acid binding protein, interleukin-18 levels and the degree of renal injury in patients with hepatitis B cirrhosis
XU Jiao1 ZHANG Ying1 WANG Yuanyuan1 ZHU Feng2▲
1. The Sixth Department of Hepatopathy, Dalian Public Health Clinical Center, Liaoning Province, Dalian 116031, China;
2. The Second Department of Nephrology, Xinhua Hospital Affiliated to Dalian University, Liaoning Province, Dalian 116021, China
Abstract：Objective To study the correlation between urine liver-type fatty acid binding protein (L-FABP), interleukin-18 (IL-18) levels and the degree of renal injury in patients with hepatitis B cirrhosis. Methods The clinical data of 90 patients with hepatitis B cirrhosis complicated with renal injury who were admitted to Dalian Public Health Clinical Center from February 2020 to June 2021 were retrospectively analyzed. According to the relevant staging criteria of acute kidney injury (AKI), 40 patients in AKI Ⅰ were included in the mild group, and 50 patients in AKI Ⅱ and Ⅲ were included in the severe group. Meanwhile, the clinical data of 40 patients with hepatitis B cirrhosis but without renal injury were selected as the control group. The levels of L-FABP and IL-18 in the urine of the three groups were detected and compared, and the relationship between the levels of L-FABP and IL-18 in the urine of patients with hepatitis B cirrhosis and the degree of renal injury was analyzed. Results The levels of urine L-FABP and IL-18 of patients in the severe group were higher than those in the control group and the mild group, the differences were statistically significant (P＜0.05). The levels of urine L-FABP and IL-18 of patients in the mild group were higher than those in the control group, the differences were statistically significant (P＜0.05). Spearman correlation analysis showed that the levels of urine L-FABP and IL-18 were positively correlated with the degree of renal injury in patients with hepatitis B liver cirrhosis (P＜0.05). Conclusion For patients with hepatitis B cirrhosis, the more severe the renal injury, the higher the levels of urine L-FABP and IL-18.
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