Application effect of Pentoxifylline Injection in patients with transient ischemic attack
YAN Jixi1 2
1. School of Medicine, Wuhan University of Science and Technology, Hubei Province, Wuhan 430065, China;
2. Department of Emergency Medicine, Affiliated Hospital of Jianghan University, the Sixth Hospital of Wuhan City, Hubei Province, Wuhan 430015, China
Abstract：Objective To explore the application effect of Pentoxifylline Injection on transient ischemic attack (TIA). Methods A total of 94 TIA patients admitted to Wuchang Hospital Affiliated to Wuhan University of Science and Technology from May 2018 to May 2020 were selected as the research subjects, and they were divided into control group and experimental group by lottery, with 47 patients in each group. Patients in the control group were given routine TIA attack treatment, while patients in the experimental group were additionally treated with Pentoxifylline Injection on the basis of the contrpl group. The clinical efficacy, cerebral blood flow parameters (the average blood flow [Qmean], maximum flow rate [Vmax], minimum velocity [Vmin]), CT perfusion imaging parameters (mean traansit time [MTT], time to peak [TTP], cerebral blood volume [CBV], cerebral blood flow [CBF]), vascular endothelial function (vascular endothelial growth factor [VEGF], vascular endothelin-1 [ET-1], nitric oxide [NO]) before and after treatment, adverse reactions, recurrence rate of TIA, incidence of cerebral infarction of two groups were conpared. Results The total effective rate in experimental group was higher than that in control group, and the difference was statistically significant (P<0.05). After treatment, Qmean, Vmax and Vmin in the experimental group were higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, MTT and TTP of the experimental group were lower than those of the control group, while CBV and CBF were higher than those of the control group, the differences were statistically significant (P<0.05). After treatment, VEGF and ET-1 in experimental group were lower than those in control group, and NO was higher than that in control group, the differences were statistically significant (P<0.05). The recurrence rate of TIA and incidence of cerebral infarction in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion Pentoxifylline Injection in the treatment of patients with transient ischemic attack can effectively enhance the effective rate of clinical treatment, significantly improve the cerebral blood supply and vascular endothelial function, and reduce the recurrence rate of transient ischemic attack and the incidence rate of cerebral infarction in patients, with less side effects.
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