不同人群抑郁症特点和叶酸干预的研究进展

摘要
图/表
参考文献(28)
相关文章 (15)

全文: PDF (0 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要抑郁症是一种与现代生活密切相关的常见的精神疾病，其发病率逐年上升，现有的精神健康资源存在一些不足，使得抑郁症的识别率较低、病程较长、复发率较高。儿童青少年、孕产妇、老年人等都有可能患抑郁症，不同人群抑郁症的发病原因各异，表现有所不同，在临床诊断和治疗过程中，抗抑郁药物的干预也存在一定的风险。最新的研究表明，作为一种人体生命活动必需的水溶性维生素——叶酸的缺乏，不仅可以导致胚胎期胎儿的神经管发育异常，而且还可能与抑郁症等神经精神系统疾病有关。而通过补充叶酸（特别是活性叶酸）对改善抑郁状态，调节神经递质具有一定的辅助治疗作用。针对这一发现，本文对不同人群的抑郁症特点和叶酸干预作一综述，旨在揭示叶酸在不同人群抑郁症中可能发挥的作用，为抑郁症的治疗提供一种新的思路。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	薛娟
	马文斌
	涂华
	顾睿
	刘康
	成永之
	连增林

关键词 ：抑郁症, 不同人群, 活性叶酸, 亚甲基四氢叶酸还原酶, 关联性

Abstract：Depression is a common mental disease that′s closely related to modern life, and its incidence is increasing year by year, and the existing mental health resources have some deficiencies so that the identification rate of depression is low, the disease duration is long, and the recurrence rate is high. Children and adolescents, pregnant women,older adults are at risk for depression, the onset and presentation of depression vary among different populations, and there are risks associated with antidepressant drug interventions during clinical diagnosis and treatment. The latest research shows that the deficiency of folic acid, a water-soluble vitamin, that is essential for human life activities, not only leads to abnormal neural tube development in the fetus during the embryonic period, but may also be associated with neuropsychiatric disorders such as depression. While supplementation of folic acid (especially active folate) for improving depression status and regulating neurotransmitters has a certain adjuvant therapeutic effect. In response to this finding, this paper provides a review of depression characteristics and folic acid interventions in different populations, the aim of this paper reveals the possible role of folic acid in depression in different populations and provides a new way of thinking for the treatment of depression.

Key words： Depression Different groups of people Active folate Methylenetetrahydrofolate reductase Relevance

引用本文:

薛娟；马文斌；涂华；顾睿；刘康；成永之；连增林. 不同人群抑郁症特点和叶酸干预的研究进展[J]. 中国当代医药, 2022, 29(16): 53-56.
XUE Juan； MA Wenbin；TU Hua；GU Rui；LIU Kang； CHENG Yongzhi；LIAN Zenglin. Research progress on characteristics of depression and folic acid intervention in different populations. 中国当代医药, 2022, 29(16): 53-56.

链接本文:

https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I16/53

[1]	Smith K.Mental health：a world of depression[J].Nature，2014，515（7526）：181.
[3]	Reynolds EH.The neurology of folic acid deficiency[J].Handb Clin Neurol，2014，120：927-943.
[2]	Isacsson G，Rich CL.Antidepressant drugs and the risk of suicide in children and adolescents[J].Paediatr Drugs，2014，16（2）：115-122.
[4]	Barker MM，Beresford B，Bland M，et al.Prevalence and Incidence of Anxiety and Depression Among Children，Adolescents，and Young Adults With Life-Limiting Conditions：A Systematic Review and Meta-analysis[J].JAMA Pediatr，2019，173（9）：835-844.
[5]	McGuinness TM，Dyer JG，Wade EH.Gender differences in adolescent depression[J].J Psychosoc Nurs Ment Health Serv，2012，50（12）：17-20.
[6]	Kwong ASF，López-López JA，Hammerton G，et al.Genetic and Environmental Risk Factors Associated With Trajectories of Depression Symptoms From Adolescence to Young Adulthood[J].JAMA Netw Open，2019，2（6）：e196587.
[7]	Cipriani A，Zhou X，Del Giovane C，et al.Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents：a network meta-analysis[J].Lancet，2016，388（10047）：881-890.
[8]	Dartois LL，Stutzman DL，Morrow M.L-methylfolate Augmentation to Antidepressants for Adolescents with Treatment-Resistant Depression：A Case Series[J].J Child Adolesc Psychopharmacol，2019，29（5）：386-391.
[9]	Freeman MP，Savella GM，Church TR，et al.A prenatal supplement with methylfolate for the treatment and prevention of depression in women trying to conceive and during pregnancy[J].Ann Clin Psychiatry，2019，31（1）：4-16.
[10]	Yan J，Liu Y，Cao L，et al.Association between Duration of Folic Acid Supplementation during Pregnancy and Risk of Postpartum Depression[J].Nutrients，2017，9（11）：1206.
[11]	Li M，Zhang Y，Chen X，et al.Effectiveness of communitybased folate-oriented tertiary interventions on incidence of fetus and birth defects：a protocol for a single-blind cluster randomized controlled trial[J].BMC Pregnancy Childbirth，2020，20（1）：475.
[12]	Raghubeer S，Matsha TE.Methylenetetrahydrofolate （MTHFR），the One-Carbon Cycle，and Cardiovascular Risks[J].Nutrients，2021，13（12）：4562.
[13]	Yang J，Luo G，Chen X.Individualized Supplement of Folic Acid Based on the Gene Polymorphisms of MTHER/MTRR Reduced the Incidence of Adverse Pregnancy Outcomes and Newborn Defects[J].Niger J Clin Pract，2021，24（8）：1150-1158.
[14]	Lian Z，Chen H，Liu K，et al.Improved Stability of a Stable Crystal Form C of 6S-5-Methyltetrahydrofolate Calcium Salt，Method Development and Validation of an LC-MS/MS Method for Rat Pharmacokinetic Comparison[J].Molecules，2021，26（19）：6011.
[15]	Gareri P，De Fazio P，De Sarro G.Neuropharmacology of depression in aging and age-related diseases[J].Ageing Res Rev，2002，1（1）：113-134.
[16]	Kim JM，Stewart R，Kim SW，et al.Predictive value of folate，vitamin B12 and homocysteine levels in late-life depression[J].Br J Psychiatry，2008，192（4）：268-274.
[17]	Passeri M，Cucinotta D，Abate G，et al.Oral 5′-methyltetrahydrofolic acid in senile organic mental disorders with depression：results of a double-blind multicenter study[J].Aging （Milano），1993，5（1）：63-71.
[18]	薛娟，马文斌，涂华，等.6S-5-甲基四氢叶酸钙对小鼠免疫力的增强作用研究[J].中国医药科学，2021，11（17）：29-33.
[19]	Zhao G，Ford ES，Li C，et al.Use of folic acid and vitamin supplementation among adults with depression and anxiety：a cross-sectional，population-based survey[J].Nutr J，2011，10：102.
[20]	Miller AL.The methylation，neurotransmitter，and antioxidant connections between folate and depression[J].Altern Med Rev，2008，13（3）：216-226.
[25]	Stover PJ，Durga J，Field MS.Folate nutrition and bloodbrain barrier dysfunction[J].Curr Opin Biotechnol，2017，44：146-152.
[26]	连增林，刘康，顾锦华，等.叶酸与5-甲基四氢叶酸的生物学特征与应用[J].中国食品添加剂，2022，33（2）：230-239.
[28]	王嘉薇，尚靖，陈嘉.抗抑郁药物治疗双相情感障碍的研究进展[J].现代药物与临床，2021，36（3）：628-632.
[21]	Froese DS，Fowler B，Baumgartner MR.Vitamin B12，folate，and the methionine remethylation cycle -biochemistry，pathways，and regulation[J].J Inherit Metab Dis，2019，42（4）：673-685.
[22]	Bottiglieri T，Laundy M，Crellin R，et al.Homocysteine，folate，methylation，and monoamine metabolism in depression[J].J Neurol Neurosurg Psychiatry，2000，69（2）：228-232.
[23]	Fanet H，Capuron L，Castanon N，et al.Tetrahydrobioterin（BH4） Pathway：From Metabolism to Neuropsychiatry[J].Curr Neuropharmacol，2021，19（5）：591-609.
[24]	Papakostas GI，Shelton RC，Zajecka JM，et al.L-methylfolate as adjunctive therapy for SSRI-resistant major depression：results of two randomized，double-blind，parallel-sequential trials[J].Am J Psychiatry，2012，169（12）：1267-1274.
[27]	Bailey SW，Pfeiffer CM，Zhang M，et al.Pharmacolkinetics of oral folic acid compared to 5-methyl-（S） tetrahydrofolate in human plasma[J].FASEB J，2005，19（4）：52.