Objective To study the effect of different resection methods of hysteroscopic electroresection on the incidence of intrauterine adhesion and pregnancy outcome in patients with type Ⅱsubmucosal myoma of uterus. Methods A total of 78 patients with type Ⅱsubmucosal myoma of uterus who underwent hysteroscopic surgery at Yangjiang Maternal and Child Health Care Hospital from October 2017 to October 2020 were selected as research objects, they were divided into experimental group (n=39) and control group (n=39) according to random number table method. The experimental group used the resection method after opening the window, and the control group used the direct resection method. The perioperative indicators, follow-up indicators and pregnancy outcome were compared between the two groups. Results There were no statistically significant differences in the operation duration, intraoperative blood loss and uterine dilatation fluid dosage between the two groups (P>0.05). There was no significant difference in the recurrence rate of the two groups within 1 year after operation (P>0.05). Within 1 year after the operation, the difference in the healing rate of the myometrium between the two groups was not statistically significant (P>0.05). At the 1st and 6th months after the operation, the endometrial wound healing rate in the experimental group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Within 1 year after surgery, the incidence of intrauterine adhesions in the experimental group was lower than that in the control group, the difference was statistically significant (P<0.05). Within 1 year after operation, the success rate of pregnancy in the experimental group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Hysteroscopic electroresection after opening the window should be used in the treatment of type Ⅱsubmucosal myoma of uterus. It can promote the rapid healing of endometrial wound, prevent postoperative intrauterine adhesion, and improve the success rate of pregnancy. It has no effect on perioperative indicators, myometrial healing and postoperative recurrence rate of patients. It is worth popularizing.