To investigate the clinical efficacy of Silveralginate Wound Dressing combined with negative pressure sealing drainage technology in the rehabilitation of large woundafteranorectal surgery. Methods From January 2018 to May 2021, 120 patients with large-area woundsafteranorectal surgery who wereadmitted to the Huazhong University of Science and Technology Union Shenzhen Hospital were selected as the research objects, and they were divided into an observation group and a control group by computer randomization method, with 60 cases in each group. The observation group was treated with Silveralginate Wound Dressing combined with negative pressure sealing drainage technology, and the control group was treated with routine debridementand dressing change. The clinical efficacy, postoperative wound pain, wound debridement times, dressing changes, healing time, wound healing rate in different periodsand serum inflammatory factors were observedand compared between the two groups. Results There was no significant difference in the total effective rate between the two groups (P>0.05). The visual analogue scale score of the observation group was lower than that of the control group on the 3rd, 7th, 14th and 21st day after surgery, with statistical significance(P<0.05). The wound healing rate of the observation group was higher than that of the control group on the 3rd, 7th, 14th and 21st day after operation, and the difference was statistically significant (P<0.05). The frequency of debridementand dressing change in the observation group was less than that in the control group, and the difference was statistically significant (P<0.05). There were no significant difference in the expression levels of white blood cell count(WBC), hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) between the two groups on the 1st day after surgery (P>0.05). The levels of WBC, hs-CRP, IL-6, TNF-α in the two groups on the 7th and 14th day after surgery were lower than those on the 1st day after surgery, and the levels of WBC, hs-CRP,IL-6, TNF-α on the 14th day after surgery were lower than those on the 7th day after surgery, the levels of WBC, hs-CRP, IL-6, TNF-α on the 7th and 14th day after operation were lower than those in the control group, and the differences were statistically significant (P<0.05). Conclusion Silveralginate Wound Dressing combined with negative pressure sealing drainage technology has definite clinical efficacy inaccelerating the rehabilitation of large woundafteranorectal surgery, which can significantly reduce the pain of patients, shorten the healing time, and reduce the level of inflammatory factors. It has high clinical application value.