Abstract：Objective To investigate the diagnostic value of gastroscopic biopsy in gastric high-grade intraepithelial neoplasia. Methods A total of 82 patients diagnosed with gastric high-grade intraepithelial neoplasia who were admitted to the Affiliated Hospital of Heze Medical College from August 2018 to August 2021 were selected as the research subjects. The positive detection rate of early gastric high-grade intraepithelial neoplasia, developmental gastric highgrade intraepithelial neoplasia and total gastric high-grade intraepithelial neoplasia were analyzed using surgical pathological biopsy as the gold standard, and the consistency between gastroscopy and surgical pathological biopsy was calculated. Results The positive rate of early gastric high-grade intraepithelial neoplasia was 50.00% (41/82), that of developing gastric high-grade intraepithelial neoplasia was 47.56% (39/82), and that of total gastric high-grade intraepithelial neoplasia was 97.56% (80/82). There were no significant differences compared with surgical pathology (51.22%[42/82], 48.78% [40/82], 100.00% [82/82]). The consistency between the diagnosis of high-grade intraepithelial neoplasia of the stomach by gastroscopy biopsy and the surgical pathological section was tested with Kappa=0.833, indicating a good consistency. Conclusion The results of gastric biopsy in patients with gastric high-grade intraepithelial neoplasia are consistent with the results of surgical pathological biopsy, and the clinical diagnostic value is high, which is worthy of recommendation.
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