Abstract：Objective To discuss the effect of transnasal high flow oxygen therapy (HFNC) in noninvasive ventilation of newborn. Methods A total of 76 neonates with mechanical ventilation admitted to our hospital from February, 2015 to December 2018 were selected as subjects and divided into observation group and control group according to random number table method, 38 cases in each group. Neonates in control group were given nasal continuous positive airway pressure (NCPAP), and neonates in observation group were given HFNC. The indexes of blood gas analysis (pH, partial pressure of blood carbon dioxide [PaCO2]and oxygen [PaO2]), disappearance time of clinical symptoms and complications between two groups were compared. Results There were no significant differences in pH, PaCO2 and PaO2 between the two groups before ventilation, 24 and 72 hours after ventilation (P＞0.05). The disappearance time of dyspnea,lung rales, three concave sign and cyanosis in observation group were shorter than those in control group, the differences were significant (P＜0.05). The incidence of complications in observation group was lower than that in control group, the difference was significant significant (P＜0.05). Conclusion The effect of HFNC on neonatal noninvasive ventilation is similar to that of NCPAP, but HFNC can improve clinical symptoms and reduce complications, and the overall ventilation effect is better than that of NCPAP.
Luo J，Wu W，Mussa C，et al.1229：Comparison of HFNC and NCPAP in preterm infants with respiratory distress syndrome：a meta-analysis[J].Crit Care Med，2019，47（1）：591-596.
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