孟鲁司特钠咀嚼片与氯雷他定片联合曲安奈德鼻喷雾剂治疗儿童过敏性鼻炎的效果

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摘要目的探讨孟鲁司特钠、氯雷他定联合曲安奈德鼻喷雾剂用药方案治疗儿童过敏性鼻炎（AR）的临床效果，为儿科医师选择合理治疗方案提供参考。方法选取2017年1月至2020年12月在广州市社会福利院康复医院就诊的84 例AR 患儿作为研究对象，按随机数字表法将其分为观察组与对照组，各42 例。对照组予以氯雷他定片联合曲安奈德鼻喷雾剂治疗，观察组予以孟鲁司特钠咀嚼片、氯雷他定片联合曲安奈德鼻喷雾剂治疗。分析、比较两组患儿的治疗效果。结果两组治疗前的鼻痒、打喷嚏、流鼻涕和鼻塞症状评分比较，差异无统计学意义（P＞0.05）；两组治疗后的鼻痒、打喷嚏、流鼻涕和鼻塞症状评分低于治疗前，差异有统计学意义（P＜0.05），观察组治疗后的鼻痒、打喷嚏、流鼻涕和鼻塞症状评分低于对照组，差异有统计学意义（P＜0.05）。观察组的治疗总有效率为95.24%，高于对照组的76.19%，差异有统计学意义（P＜0.05）。结论孟鲁司特钠咀嚼片、氯雷他定片联合曲安奈德鼻喷雾剂方案治疗儿童AR 的治疗效果优于氯雷他定片联合曲安奈德鼻喷雾剂方案，三者联合用药取得的临床疗效显著，且安全性好，值得临床推广应用。

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	卢小炎
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	谢济清
	张良

关键词 ：过敏性鼻炎, 儿童, 孟鲁司特钠咀嚼片, 氯雷他定片, 曲安奈德鼻喷雾剂

Abstract：Objective To investigate the clinical effect of the medication regimen of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray in the treatment of allergic rhinitis in children,and to provide reference for pediatricians to choose reasonable treatment plan.Methods A total of 84 children with allergic rhinitis treated in the Rehabilitation Hospital of Guangzhou Social Welfare Hospital from January 2017 to December 2020 were selected as the study objects,and they were divided into the observation group (42 cases)and the control group (42 cases) according to the random number table method.The control group was treated with Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray,and the observation group was treated with Montelukast Sodium Chewable Tablets,Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray.The therapeutic effects of the two groups were analyzed and compared.Results There was no significant difference in the scores of nasal itching,sneezing,runny nose and nasal congestion between the two groups before treatment (P＞0.05).The scores of nasal itching,sneezing,runny nose and nasal congestion in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05).The scores of the nasal itching,sneezing,runny nose and nasal congestion in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The total effective rate of the observation group was 95.24%,which was higher than 76.19% of the control group,and the difference was statistically significant (P＜0.05).Conclusion The treatment effect of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray is better than that of Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray.The combination of the three drugs achieve remarkable clinical efficacy,and good safety,which is worthy of clinical promotion and application.

Key words： Allergic rhinitis Children Montelukast Sodium Chewable Tablets Loratadine Tablets Triamcinolone Acetonide Nasal Spray

引用本文:

卢小炎；卢振盛；谢济清；张良. 孟鲁司特钠咀嚼片与氯雷他定片联合曲安奈德鼻喷雾剂治疗儿童过敏性鼻炎的效果[J]. 中国当代医药, 2022, 29(14): 115-118.
LU Xiaoyan；LU Zhensheng；XIE Jiqing；ZHANG Liang. Effect of Montelukast Sodium Chewable Tablets and Loratadine Tablets combined with Triamcinolone Acetonide Nasal Spray in the treatment of allergic rhinitis in children. 中国当代医药, 2022, 29(14): 115-118.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2022/V29/I14/115

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