Clinical effect of Tegafur combined with Apatinib in the maintenance therapy of stage Ⅲcervical cancer
CHEN Chen1 WANG Haoyuan2 LIANG Meichang1
1.Department of Oncology,Jiangmen Central Hospital,Guangdong Province,Jiangmen 529000,China;
2.Department of Critical Care Medicine,Jiangmen Central Hospital,Guangdong Province,Jiangmen 529000,China
Abstract：Objective To investigate the clinical effect of Tegafur combined with Apatinib in the maintenance therapy of stage Ⅲcervical cancer.Methods The clinical data of 65 patients with cervical cancer admitted to Jiangmen Central Hospital from January 2016 to June 2017 were retrospectively analyzed.They were divided into control group (n=30) and maintenance chemotherapy group (n=35) according to different treatment methods.Both groups received the same regimens of chemoradiotherapy.After the end of chemoradiotherapy,the control group underwent regular reexamination,and the maintenance chemotherapy group received maintenance treatment of Tegafur combined with Apatinib.Treatment effect,quality of life score,progression-free survival and incidence of adverse reactions were compared between the two groups.Results The total effective rate of maintenance chemotherapy group was 71.43%,higher than 36.67% of control group,the difference was statistically significant (P<0.05).The quality of life score of the maintenance chemotherapy group was higher than that of the control group,the difference was statistically significant (P<0.05).Progression-free survival was (11.46±2.01) months in the maintenance chemotherapy group,longer than (9.35±1.24) months in the control group,the difference was statistically significant (P<0.05).There was no significant difference in the incidence of bone marrow suppression,edema,gastrointestinal reaction and hypertension between the two groups (P>0.05).The incidence of hand-foot syndrome in the maintenance chemotherapy group was higher than that in the control group,the difference was statistically significant (P<0.05).Conclusion In patients with stage Ⅲcervical cancer,maintenance therapy with Tegafur combined with Apatinib is effective,beneficial to improve quality of life and prolong survival time without increasing serious adverse reactions.
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