Abstract:Objective To investigate the effect of Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease. Methods A total of 100 patients with arrhythmia of coronary heart disease admitted to our hospital from January 2018 to December 2019 were selected as the study objects. According to the random envelope method, they were divided into the control group (50 cases) and the experimental group (50 cases). The control group was treated with Amiodarone, and the experimental group was treated with Amiodarone and Metoprolol. The blood pressure, premature contraction and the total effective rate of clinical treatment were compared between the two groups.Results There were no significant differences between the two groups in blood pressure changes and premature contractions before treatment (P>0.05). The systolic blood pressure and diastolic blood pressure after treatment in the two groups were lower than those before treatment, the differences were statistically significant (P<0.05). After treatment,the systolic and diastolic blood pressure in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05). The number of ventricular premature contraction and atrial premature contraction in the experimental group were less than those in the control group, the differences were statistically significant (P<0.05). The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease can improve blood pressure, reduce the incidence of ventricular premature beats and atrial premature beats, and promote the total effective rate of clinical treatment.