Abstract：Objective To explore the effect of different doses of Metoprolol combined with Vildagliptin in the treatment of coronary heart disease complicated with diabetes.Methods A total of 110 patients with coronary heart disease complicated with diabetes in Tengzhou Hospital of Traditional Chinese Medicine from May 2019 to February 2021 were selected as the research subjects,and were divided into study group and routine group according to random number table method,with 55 patients in each group.Both groups were treated with Vildagliptin combined with Metoprolol,the dosage of Metoprolol in the study group was 12.5 mg/time,twice a day.The dosage of Metoprolol in conventional group was 25 mg/time,twice a day.Treatment effect,cardiac function indexes (left ventricular ejection fraction[LVEF],left ventricular end-systolic diameter[LVESD],left ventricular end-diastolic diameter[LVEDD]),blood glucose indexes(fasting blood glucose[FPG],2 h postprandial blood glucose[2 h PG],glycosylated hemoglobin[HbA1c]),total incidence of adverse reactions,and serum inflammatory factors (Interleukin-6[IL-6],interleukin-8[IL-8],C-reactive protein[CRP]and tumor necrosis factor-α[TNF-α]) before and after treatment were compared between two groups.Results There was no significant difference in the total effective rate between two groups (P>0.05).The levels of FPG,2 h PG and HbA1c in two groups after treatment were lower than those before,and the levels of FPG,2 h PG and HbA1c in the study group were lower than those in the conventional group after treatment,the differences were statistically significant (P<0.05).After treatment,LVEF in the study group was higher than that in the conventional group,LVESD,LVEDD in the study group were lower than those in the conventional group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the conventional group,the difference was statistically significant (P<0.05).After treatment,the levels of IL-6,IL-8,CRP and TNF-α in two groups were lower than those before,and the levels of IL-6,IL-8,CRP and TNF-α in study group were lower than those in control group,the differences were statistically significant (P<0.05).Conclusion When different doses of Metoprolol combined with Vildagliptin in the treatment of patients with coronary heart disease complicated with diabetes,the dose should be controlled at 12.5 mg/time,which can not only ensure the therapeutic effect,but also improve the control level of blood glucose in patients,help to reduce the incidence of adverse reactions in patients and improve the level of inflammatory factors in patients.
周立宇. 不同剂量美托洛尔联合维格列汀治疗冠心病合并糖尿病的应用效果[J]. 中国当代医药, 2022, 29(14): 58-62.
ZHOU Liyu. Effect of different doses of Metoprolol combined with Vildagliptin in the treatment of coronary heart disease complicated with diabetes. 中国当代医药, 2022, 29(14): 58-62.
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