Abstract：Objective To explore the effect of anaesthetic to electrical stimulus time interval (ASTI) on electrographic seizure duration (ESD) in modified electro-convulsive therapy (MECT). Methods A total of 102 schizophrenic patients treated with MECT in Shanghai Jinshan Mental Health Center from July 2017 to February 2021 were selected as the research objects. A real-world clinical research was used to record the ASTI and ESD of all patients during 6 consecutive MECT (612 times). The effect of ASTI on ESD were analyzed, and the regulatory effect of gender and treatment times on this effect were further investigated. Results ESD of male schizophrenic patients was longer than that of female patients, the difference was statistically significant (P＜0.05). The first and second ESD were longer than the sixth ESD, and the difference was statistically significant (P＜0.05). There was no significant difference between the ESD at the 3rd, 4th and 5th treatments and the ESD at the 6th treatment (P＞0.05). ASTI positively affected ESD, and the difference was statistically significant (P ＜0.05). Energy negatively affected ESD, the difference was statistically significant (P＜0.05). There was no significant difference in the effects of body weight, age, Propofol dose and SC dose on ESD (P＞0.05). ASTI had a positive effect on ESD in male and female patients with schizophrenia (P＜0.05). The effect on male schizophrenic patients was greater than that on female patients, and the difference between the two influence coefficients was 0.013, the difference was statistically significant (P＜0.05). ASTI positively affected ESD during the 1st treatment to 6th treatment (P ＜0.05). With the increase of the number of treatments, the influence coefficient gradually decreased, and the difference between the first and sixth influence coefficient was 0.072, the difference was statistically significant (P＜0.05). Conclusions Appropriate extension of ASTI can increase the ESD induced by MECT and improve the quality of epileptic seizures, which is worthy of clinical promotion.
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