Abstract：Objective To investigate the effect of Agattroban adjuvant therapy in acute ischemic stroke patients with early neurological deterioration. Methods A total of 160 patients with acute ischemic stroke admitted to the First People′s Hospital of Zhangjiagang City from June 2018 to June 2021 were selected as the study subjects. They were divided into group A and group B by random touch ball method, with 80 cases in each group. Patients in group B were treated with Aspirin, and patients in group A were treated with Agattroban. The degree of cerebral nerve function defect, the level of fibrinogen (FIB) and neuropeptide (NPY) in the two groups were compared. Results The modified Edinburgh-Scandinavian neurological impairment score scale (MIESSS) scores of the two groups after treatment were lower than those before treatment, and the MIESSS score of group A was lower than that in the group B, the differences were statistically significant (P<0.05). After treatment, FIB and NPY levels in the two groups were lower than those before treatment, and FIB and NPY levels in group A were lower than those in group B, the differences were statistically significant (P<0.05). Conclusion In acute ischemic stroke patients with early neurological deterioration, adjunctive treatment with Agattroban can significantly reduce the degree of cerebral neurological impairment and regulate the level of FIB and NPY.
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