Effect of Milrinone combined with Trimetazidine on hemodynamics and heart rate variability in patients with congestive heart failure
YAN Bo-yu1 LIU Ting1 DU Qian1 PAN Li-hua2▲
1.Department of Cardiovascular Medicine，People′s Hospital of Pingxiang City，Jiangxi Province，Pingxiang 337000，China;
2.Department of Cardiovascular Medicine，Affiliated Hospital of Nantong University，Jiangsu Province，Nantong 226021，China
Abstract：Objective To investigate the effect of Milrinone combined with Trimetazidine on hemodynamics and heart rate variability in patients with congestive heart failure (CHF).Methods A total of 100 patients with CHF who were admitted to People′s Hospital of Pingxiang City in Jiangxi Province from October 2017 to October 2019 were selected as the research objects and divided into two groups according to random number table method，with 50 cases in each group.The control group was treated with oral Trimetazidine，and the observation group was treated with Milrinone on the basis of the control group，with 1 week of treatment in two groups.The curative effect，cardiac function (left ventricular end systolic diameter[LVESD]，left ventricular end diastolic diameter[LVEDD]，interventricular septal thickness[IVST]，left ventricular posterior wall thickness [LVPWT]，N-terminal pro-brain natriuretic peptide [NT-proBNP])，hemodynamics (cardiac index [CI]，cardiac output [CO])，heart rate variability (standard deviation of normal to normal intervals [SDNN]，standard deviation of per 5 min averages normal number of intervals [SDANN]，24 h adjacent R-R interval difference＞50 ms percentage [PNN50]，low frequency [LF]，high frequency [HF]，LF/HF) and the adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group，and the difference was statistically significant (P ＜0.05).The levels of LVESD，LVEDD，IVST，LVPWT and NT-proBNP in the observation group were lower than those in control group，the levels of CI，CO，SDNN，SDANN，PNN50，LF，HF，LF/HF in the observation group were higher than those in the control group，and the differences were statistically significant (P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion Milrinone combined with Trimetazidine in the treatment of patients with CHF can improve hemodynamics and heart rate variability indexes，protect car diac function and have higher safety，which provides theoretical basis and new ideas for clinical promotion and application.
闫博宇；刘 婷；杜 倩；潘丽华. 米力农联合曲美他嗪对充血性心力衰竭患者血流动力学、心率变异性的影响[J]. 中国当代医药, 2020, 27(33): 62-65.
YAN Bo-yu；LIU Ting；DU Qian；PAN Li-hua. Effect of Milrinone combined with Trimetazidine on hemodynamics and heart rate variability in patients with congestive heart failure. 中国当代医药, 2020, 27(33): 62-65.
Kawashima S，Yamashita T，Ozaki M，et al.Endothelial NO synthase overexpression inhibits lesion formation in mouse model of vascular remodeling[J].Anerioscler Thromb Vasc Biol，2001，21（2）：201-207.
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