利那洛肽联合复方聚乙二醇电解质散在结肠镜肠道准备中的应用效果

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摘要目的探讨利那洛肽联合复方聚乙二醇电解质散在结肠镜检查前肠道准备中的作用效果及安全性。方法选取2020年1～6月于上海交通大学医学院附属苏州九龙医院拟行结肠镜检查的156例患者作为研究对象，采用随机数字表法将其分为对照组、观察组A、观察组B，每组各52例。对照组患者采用3盒复方聚乙二醇电解质散清肠，观察组A患者采用利那洛肽联合2盒复方聚乙二醇电解质散清肠，观察组B 患者采用2盒复方聚乙二醇电解质散清肠。比较三组患者的肠道清洁度及不良反应总发生率。结果观察组B 的左半结肠、横结肠、右半结肠评分及Boston 肠道准备量表（BBPS）总评分均低于对照组，差异有统计学意义（P＜0.05）；观察组A 的左半结肠、横结肠、右半结肠评分及BBPS 总评分与对照组比较，差异均无统计学意义（P＞0.05）。观察组A 的左半结肠、横结肠、右半结肠评分及BBPS 总评分高于观察组B（P＜0.05），观察组A、B 的不良反应总发生率均低于对照组，差异有统计学意义（P＜0.05）；观察组A 的不良反应总发生率与观察组B 比较，差异无统计学意义（P＞0.05）。结论利那洛肽联合2盒复方聚乙二醇电解质散的肠道准备方式，与单用3盒复方聚乙二醇电解质散的肠道准备效果基本相当，且可以降低肠道准备过程中的不良反应总发生率，安全性较高。其肠道清洁效果也优于单用2盒复方聚乙二醇电解质散。

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	汪伟
	温巧生

关键词 ：结肠镜, 肠道准备, 复方聚乙二醇电解质散, 利那洛肽

Abstract：Objective To explore the application effect and safety of Linaclotide combined with Compound Polyethylene Glycol Electrolyte Powder in bowel preparation before colonoscopy.Methods A total of 156 patients who underwent colonoscopy in Suzhou Kowloon Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January to June 2020 were selected as study objects and divided into the control group，observation group A and observation group B by random number table method，with 52 cases in each group.The control group was given 3 bags of Compound Polyethylene Glycol Electrolyte Powder to clear the intestines，the observation group A was given Linaclotide combined with 2 bags of Compound Polyethylene Glycol Electrolyte Powder to clear the intestine，and the observation group B was given 2 bags of Compound Polyethylene Glycol Electrolyte Powder to clear the intestine.Intestinal cleanliness and the incidence of adverse reactions of patients in each group were compared.Results The scores of left semicolon，transverse colon，right semicolon and total Boston bowel preparation-aration scale (BBPS) in observation group B were lower than those in the control group，and the differences were statistically significant (P＜0.05).There were no statistically significant differences in the scores of left semicolon，transverse colon，right semicolon and total BBPS between the observation group A and the control group (P＞0.05).The scores of left semicolon，transverse colon，right semicolon and total BBPS in observation group A were higher than those in the obeservation group B (P＜0.05).The total incidence of adverse reactions in observation group A and observation group B were both lower than those in the control group，and the differences were statistically significant (P＜0.05).There was no statistically significant difference in total incidence of adverse reactions between observation group A and observation group B (P＞0.05).Conclusion The intestinal preparation effect of Linaclotide combined with 2 bags of Compound Polyethylene Glycol Electrolyte Powder is approximately the same as that of 3 bags of Compound Polyethylene Glycol Electrolyte Powder，and it can reduce the total incidence of adverse reactions in the process of intestinal preparation，and has higher safety.Its intestinal cleaning effect is also better than that of 2 bags of Compound Polyethylene Clycol Electrolyte Powder.

Key words： Colonoscopy Bowel preparation Compound Polyethylene Glycol Electrolyte Powder Linaclotide

作者简介: 汪伟（1984-），男，安徽黄山人，本科，主治医师，研究方向：消化系统常见疾病的诊治以及消化内镜下各种疾病的诊断与治疗

引用本文:

汪伟；温巧生. 利那洛肽联合复方聚乙二醇电解质散在结肠镜肠道准备中的应用效果[J]. 中国当代医药, 2020, 27(33): 13-16.
WANG Wei；WEN Qiao-sheng. Application effect of Linaclotide combined with Compound Polyethylene Glycol Electrolytes Powder in bowel preparation for colonoscopy. 中国当代医药, 2020, 27(33): 13-16.

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https://www.dangdaiyiyao.com/CN/ 或 https://www.dangdaiyiyao.com/CN/Y2020/V27/I33/13

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