Comparisons of the clinical effect of Losartan and Captopril in the treatment of hypertensive nephropathy
LIN Xiujuan1 CHEN Jinzao2 ZHENG Liru2
1.Department of Cardiothoracic Surgery,the First Hospital of Putian,Fujian Province,Putian 351100,China;
2.Department of Cardiology,the First Hospital of Putian,Fujian Province,Putian 351100,China
Abstract：Objective To explore the clinical effects of Losartan and Captopril in the treatment of hypertensive nephropathy.Methods A total of 60 patients with hypertensive nephropathy admitted to the Department of Cardiology of the First Hospital of Putian From July 2020 to June 2021 were selected as the research subjects,they were divided into Losartan group and Captopril group by drawing lots method,with 30 cases in each group.Two groups of patients were treated with Losartan and Captopril respectively.The systolic and diastolic blood pressures,estimated glomerular filtration rate(eGFR),the difference between the eGFR(△eGFR)before and after treatment and the total incidence of complications during the treatment were compared between the two groups.The blood creatinine levels of the two groups were collected and were used for the calculations of the eGFR.Results Before treatment,there were no significant differences in systolic blood pressure,diastolic blood pressure,and eGFR between the two groups(P＞0.05).After treatment,the systolic blood pressure of the two groups was lower than that before treatment,and the systolic blood pressure of the Losartan group was lower than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,the diastolic blood pressure of the two groups was lower than that before treatment,and the diastolic blood pressure of the Losartan group was lower than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,the eGFR of the two groups was higher than that before treatment,and the eGFR of the Losartan group was higher than that of the Captopril group,the differences were statistically significant(P＜0.05).After treatment,△eGFR in the Losartan group was higher than that of the Captopril group,and the difference was statistically significant(P＜0.01).The total incidence of the complications in the Losartan group(13.30%)was lower than that in the Captopril group(36.70%),the difference was significant(P=0.037).Conclusion From the effect of lowering blood pressure and improving renal function,both drugs can reduce blood pressure,improve renal function and reduce the incidence of adverse drug reactions,thereby preventing the progression of renal disease.Losartan is better than Captopril in the treatment of hypertensive nephropathy.
林秀娟;陈金灶;郑丽如. 氯沙坦与卡托普利治疗高血压肾病的临床效果比较[J]. 中国当代医药, 2022, 29(10): 128-131.
LIN Xiujuan; CHEN Jinzao; ZHENG Liru. Comparisons of the clinical effect of Losartan and Captopril in the treatment of hypertensive nephropathy. 中国当代医药, 2022, 29(10): 128-131.
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