Expression levels and clinical significance of urinary L-FABP, NGAL,KIM-1, and β2-MG kidney injury markers in patients with chronic obstructive pulmonary disease
XU Jinxiong1 CAO Dongdong2 CAO Xiaoquan2▲
1. Department of Nephrology, the Third People′s Hospital of Jiujiang City, Jiangxi Province, Jiujiang 332000, China;
2. Department of Tuberculosis, the Third People′s Hospital of Jiujiang City, Jiangxi Province, Jiujiang 332000, China;
Abstract：Objective To analyze the expression levels of kidney injury markers including urinary hepatic fatty acidbinding protein (L-FABP), neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and β2-microglobulin (β2-MG) in patients with chronic obstructive pulmonary disease (COPD) and their clinical significance. Methods A total of 90 COPD patients who were treated into the Third People′s Hospital of Jiujiang City from January 2020 to June 2021 were selected as the observation group. According to different arterial oxygen partial pressure (PaO2), they were divided into the observation group 1 (60 mmHg < PaO2 ≤85 mmHg), the observation group 2 (40 mmHg < PaO2 ≤60 mmHg), and the observation group 3 (PaO2 ≤40 mmHg). Meanwhile, 50 healthy volunteers who underwent physical examinations in the Third People′s Hospital of Jiujiang City during the same period were selected as the control group. All four groups were deprived of water after 8:00 pm, and urine samples were collected from the clean mid-section in the next morning. L-FABP, NGAL, and KIM-1 were detected by enzyme-linked immunosorbent assay, and β2-MG was detected by immunoturbidimetric method. The levels of urinary L-FABP, NGAL,KIM-1, and β2-MG in the observation group, each subgroup, and the control group were compared, and the correlation between L-FABP, NGAL, KIM-1, and β2-MG and PaO2 were analyzed. Results The levels of L-FABP, NGAL,KIM-1, and β2-MG in the observation group 3 were higher than those in the observation group 1, the observation group 2, and the control group, the levels of L-FABP, NGAL, KIM-1, and β2-MG in the observation group 2 were higher than those in the observation group 1 and the control group, the levels of L-FABP, NGAL, KIM-1, and β2-MG in the observation group 1 were higher than those in the control group, with statistical differences (P<0.05). Pearson correlation test showed that the levels of L-FABP, NGAL, KIM-1, and β2-MG were negatively correlated with PaO2 (P<0.05).Conclusion PaO2 in COPD patients is correlated with the levels of L-FABP, NGAL, KIM-1, and β2-MG. The measurement of urinary L-FABP, NGAL, KIM-1, and β2-MG levels can reflect early renal injury. With the severity of hypoxia, the renal damage of the patients also aggravates, which can provide a reference for the early intervention and treatment of COPD.
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