Objective To explore the application effect of nourishing touch with parental involvement on premature infants. Methods A total of 100 premature infants admitted to neonatal intensive care unit (NICU) of Yichun Maternal and Child Health Care Hospital from October 2019 to June 2020 were selected as the study subjects, and they were divided into the nourishing touch group (n=50) and the routine group (n=50) according to the lottery (paper sticks with numbers 1-100 were made, according to the odevity of the numbers drawn). The routine group was given routine developmental support intervention, and the nourishing touch group was given nourishing touch with parental involvement for intervention. The body weight change, neonatal behavioral neurological assessment (NBNA), the occurrence of adverse reactions, daily sleep time, hospital stay and family satisfaction were compared between the two groups. Results The body weights of the two groups at 3 weeks of intervention were heavier than those before intervention, the differences were statistically significant (P＜0.05). The body weight in the nourishing touch group at 3 weeks of intervention was heavier than that in the routine group, the difference was statistically significant (P＜0.05).The NBNA scores at 1, 2 and 3 weeks of intervention in the two groups were higher than those before intervention, the differences were statistically significant (P＜0.05). The NBNA scores in the nourishing touch group at 1, 2 and 3 weeks of intervention were higher than those in the routine group, the differences were statistically significant (P＜0.05). The total incidence rate of adverse reactions at 3 weeks of intervention in the nourishing touch group was lower than that in the routine group, the difference was statistically significant (P＜0.05). The daily sleep time in the nourishing touch group was longer than that in the routine group, while the hospital stay in the nourishing touch group was shorter than that in the routine group, and the measure of processes of care (MPOC-20) score in the nourishing touch group was higher than that in the routine group, the differences were statistically significant (P＜0.05). Conclusion Nourishing touch with parental involvement can speed up the growth and development of premature infants, reduce the incidence rates of adverse reactions and improve the family satisfaction.