Objective To explore the application effect of health education based on WeChat platform in cervical cancer screening of women of childbearing age. Methods A total of 240 women of childbearing age who underwent cervical cancer screening in Jingdezhen First People′s Hospital from December 2019 to December 2020 were selected as the research objects. They were randomly divided into observation group and control group, with 120 cases in each group.The observation group received health education based on WeChat platform, and the control group received routine intervention. The mastery of health knowledge, psychological state and satisfaction of the two groups were compared. Results The awareness rate of health knowledge in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The total nursing satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion WeChat has high application value in cervical cancer screening of women of childbearing age, and can improve patients′ mastery of disease knowledge.