Expression and biological behavior of Rac1 protein in colorectal cancer: a Meta-analysis
XU Juan1 XIE Min-juan1▲ XU Shi-zhang2
1.School of Medicine,Yichun University,Jiangxi Province,Yichun 336000,China;
2.Department of Nephrology,Affiliated Hospital of Yichun University,Jiangxi Province,Yichun 336000,China
Abstract：[Abstract]Objective To systematically evaluate the expression and biological behavior of Rac1 protein in colorectal cancer (CRC).Methods Literatures were searched related to Rac1 protein and CRC from the databases of China National Knowledge Infrastructure (CNKI),Wanfang,China Biology Medicine disc (CBM),PubMed,Google Scholar.The retrieval time was from January 1990 to November 2019.Meta-analysis was performed using Review Manager 5.3.Results Finally,six literatures including 1011 cases were included.The expression rate of Rac1 protein in CRC was higher than that in normal tissues,with statistically significant difference (OR=79.97,95%CI 4.65-1374.11,P=0.003).The expression rate of Rac1 protein in stage Ⅰand Ⅱof CRC was lower than that in stage Ⅲand Ⅳ,with statistically significant difference (OR=0.26,95%CI 0.10-0.67,P=0.005).The expression rate of Rac1 protein in low differentiated cancer specimens was higher than that in high differentiated cancer specimens,with statistically significant difference(OR=2.51,95%CI 1.55-4.06,P=0.0002).The expression rate of Rac1 protein in CRC with lymph node metastasis was higher than that without lymph node metastasis,with statistically significant difference (OR=2.56,95%CI 1.36-4.82,P=0.004); and the expression rate of Rac1 protein in CRC with distant metastasis was higher than that without distant metastasis group,with statistically significant difference (OR=11.64,95%CI 5.71-23.70,P＜0.000 01).Conclusion Rac1 protein expression is closely related to the occurrence and development,invasion and metastasis,prognosis and other biological behaviors of CRC.
Nguyen LK，Kholodenko BN，Von Kriegsheim A.Rac1 and RhoA：Networks，loops and bistability[J].Small GTPases，2018，9（4）：316-321.
[2]
Cardama GA，Alonso DF，Gonzalez N，et al.Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms：Opportunities in cancer therapeutics[J].Crit Rev Oncol Hematol，2018，124（2）：29-36.
Gao X，Xu W，Lu T，et al.MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1[J].Technol Cancer Res Treat，2018，17：15330338187 90508.
[6]
Zhou K，Rao J，Zhou ZH，et al.RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3[J].Lab Invest，2018，98（8）：989-998.
Croise P，Brunaud L，Toth P，et al.Inhibition of Cdc42 and Rac1 activities in pheochromocytoma，the adrenal medulla tumor[J].Small GTPases 2017，8（2）：122-127.
[12]
Bright MD，Clarke PA，Workman P，et al.Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling[J].Cell Signal，2018，44（3）：127-137.
[13]
Caggia S，Chunduri H，Millena AC，et al.Novel role of Giα2 in cell migration：Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells[J].J Cell Physiol，2018，234（1）：802-815.
[14]
Tian Y，Xu L，He Y，et al.Knockdown of RAC1 and VASP gene expression inhibits breast cancer cell migration[J].Oncol Lett，2018，16（2）：2151-2160.
[15]
Ruiz-Lafuente N，Minguela A，Parrado A.DOCK9 induces membrane ruffles and Rac1 activity in cancer HeLa epithelial cells[J].Biochem Biophys Rep，2018，22（14）：178-181.
[16]
Guo Y，Zhu J，Wang X，et al.Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway[J].Med Sci Monit，2019，25：9227-9236.
Marei H，Malliri A.Rac1 in human diseases：The therapeutic potential of targeting Rac1 signaling regulatory mechanisms[J].Small GTPases，2017，8（3）：139-163.
[18]
Liang Y，Wang S，Zhang Y.Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triplenegative breast cancer epithelial cells through the RhoA/Rac1 pathway[J].Oncol Lett，2018，16（3）：3481-3488.
[19]
Yoon C，Cho SJ，Chang KK，et al.Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stemlike Cell Phenotypes in Gastric Adenocarcinoma[J].Mol Cancer Res，2017，15（8）：1106-1116.
京公网安备 11010502046607号