Objective To investigate the clinical effect of traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine in the treatment of cervical spondylosis. Methods A total of 70 patients with cervical spondylosis admitted to Beijing Fengsheng Traditional Chinese Medicine Orthopaedic Specialty Hospital and Financial Street Community Health Service Center from July 2018 to July 2020 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 35 cases in each group. Patients in the control group were treated with traditional Chinese medicine orally, while patients in the observation group were treated with traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine. The total effective rate, quality of life score, anxiety and depression mood score were compared between the two groups. Results The total effective rate of observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Before treatment, there was no statistically significant difference in quality of life score between the two groups (P>0.05). After treatment, the scores of quality of life in the two groups were higher than those before treatment, and the score of quality of life in observation group was higher than that in control group, the differences were statistically significant (P<0.05). Before treatment,there were no statistically significant differences in anxiety and depression scores between the two groups (P>0.05). After treatment, the scores of anxiety and depression in the two groups were lower than those before treatment, and the scores of depression and anxiety in observation group were lower than those in control group, the differences were statistically significant (P＜0.05). Conclusion In the clinical treatment of patients with cervical spondylosis, the implementation of traditional Chinese medicine orthopedic manipulation combined with oral administration of traditional Chinese medicine has better therapeutic effect. After its implementation, the total effective rate is higher, and it can more effectively improve the quality of life of patients. It has more advantages and is worth popularizing in clinical application.