Objective To investigate the efficacy and safety of low-collar small incision minimally invasive technique in the treatment of benign thyroid tumors. Methods Sixty patients who underwent surgical treatment of benign thyroid tumors in the First People′s Hospital of Jingdezhen City from July 2020 to July 2021 were selected as research objects,they were divided into control group and observation group according to random number table method, with 30 cases in each group. Patients in control group received thyroidectomy, and patients in observation group received low-collar small incision surgery. Compare the effect of surgical treatment between two groups, compare the general operation conditions (including surgical incision length, operation time, intraoperative blood loss, postoperative hospital stay, etc.),compare the prognosis scores (visual analogue scale [VAS], postoperative quality score) and record postoperative bleeding, dyspnea and other complications. Results The clinical effective rate of surgical treatment in observation group was higher than that in control group,and the difference was statistically significant(P<0.05).The surgical incision length,operation time, and postoperative hospital stay of observation group were shorter than those in control group, the intraoperative blood loss was less than that in control group, the VAS score of observation group was lower than that of control group, and the scores of physical function, social function, mental function and mental life of observation group were higher than those of control group, and the differences were statistically significant (P<0.05). The total incidence of postoperative complications in observation group was lower than that in control group, and the difference was statistically significant(P<0.05).Conclusion The clinical effect of low-collar small incision in the treatment of patients with benign thyroid tumors is better than traditional resection, and the surgical incision is small, the whole body impact is little, and the hospital stay can be shortened, the postoperative quality of life is higher, and postoperative complications occur less, it is worthy of clinical application and reference.