Correlation of anxiety or depression and medication compliance in patients with multidrug-resistant tuberculosis
GUI Min1 CHEN Jingfang2▲ DENG Guofang3 ZENG Guqing
1. School of Nursing, University of South China, Hu′nan Province, Hengyang 421001, China;
2. Grade ⅢHospitals Create Office,National Clinical Research Center for Infectious Disease,the Third People′s Hospital of Shenzhen,Guangdong Province, Shenzhen 518112, China;
3. The Second Department of Pulmonary Diseases, National Clinical Research Center for Infectious Disease, the Third People′s Hospital of Shenzhen, Guangdong Province, Shenzhen 518112, China
Abstract：Objective To explore the correlation of anxiety or depression and medication compliance in patients with multidrug-resistant tuberculosis. Methods A total of 91 patients with multidrug-resistant tuberculosis (MDR-TB) who were treated in Shenzhen Third People′s Hospital from December 2020 to May 2021 were selected as the research subjects. The patient′s anxiety/depression score was evaluated by the Hospital Anxiety and Depression Scale, and the patient′s medication adherence score was evaluated by the Morisky Medication Adherence Scale. There were three groups of symptoms and use analysis of variance to compare the medication adherence scores of patients with different anxiety/depression symptoms in the three groups, and use Pearson linear correlation analysis to explore the correlation between anxiety/depression and medication adherence in patients. Results The average score of medication compliance in multidrug tuberculosis patients was (6.15±1.09) points, 12 patients (13.2%) had good medication compliance, 37 patients(40.7%) were moderate, and 42 patients (46.1%) were poor. The mean score of the condition was (9.11±3.26) points, and the mean score of the depression condition was (10.06±3.26) points. Comparing the compliance scores of the three groups of patients with different anxiety status, the differences were statistically significant (P<0.05). Comparing the compliance scores of the three groups of patients with different depression status, the differences were statistical ly significant (P<0.05). The results of multiple comparisons showed that there were significant differences in the compliance scores of the three groups of patients with different anxiety/depression conditions (P<0.05). The results of Pearson linear correlation analysis showed that the scores of anxiety and medication compliance were negatively correlated (r=-0.785, P＜0.05). The scores of depression were negatively correlated with medication compliance (r=-0.930, P＜0.05). Conclusion MDR-TB patients have poor medication compliance, and patients with more severe anxiety/depression have poor medication compliance.
Alegria-Flores K，Weiner B，Wiesen C，et al.Innovative approach to the design and evaluation of treatment adherence interventions for drug-resistant TB[J].Int J Tuberc Lung Dis，2017，21（11）：1160-1166.
[10]
Morisky DE，Ang A，Krousel-Wood M，et al.Predictive validity of a medication adherence measure in an outpatient setting[J].J Clin Hypertens（Greenwich），2008，10（5）：348-354.
[11]
Zigmond AS，Snaith RP.The Hospital Anxiety and Depression Scale[J].Acta Psychiatr Scand，1983，67（6）：361-370.
Naidoo P，Dick J，Cooper D.Exploring tuberculosis patients adherence to treatment regimens and prevention programs at a public health site[J].Qual Health Res，2009，19（1）：55.
京公网安备 11010502046607号