Significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism
WANG Zhi1 HE Qin2 LIN Yuanyuan3 LIU Xiaohui
1. Department of Rheumatology, Jiangxi Children′s Hospital, Jiangxi Province, Nanchang 330006, China;
2. Department of Occupational Disease, Jiangxi Institute of Occupational Disease Prevention, Jiangxi Province, Nanchang 330006, China;
3. Department of Hematology, Jiangxi Children′s Hospital, Jiangxi Province, Nanchang 330006, China
Abstract：Objective To explore the significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism. Methods A total of 50 children with lead poisoning admitted in Jiangxi Children′s Hospital from June 2019 to December 2020 were selected as research subjects. The levels of peripheral blood immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), T-lymphocyte subsets (CD3+, CD4+, CD8+) and natural killer (NK) cells CD16+ were compared before and after treatment. The levels of IgA, IgG and IgM in children with different prognosis were compared before and after treatment. Results The levels of IgA, IgG and IgM after treatment were higher than those before treatment, the differences were statistically significant(P<0.05). The levels of CD3+, CD4+ and CD16+ after treatment were higher than those before treatment, while the levels of CD8+were lower than those before treatment, the differences were statistically significant (P<0.05). The levels of IgA,IgG and IgM in cured group and non-cure group after treatment were higher than those before treatment, and the levels of IgA, IgG and IgM in cured group before and after treatment were higher than those in non-cure group, the differences were statistically significant (P<0.05). After treatment, the levels of CD3+, CD4+ and CD16+ in cured group and non-cure group were higher than those before treatment, while the levels of CD8+ were lower than those before treatment, and the levels of CD3+, CD4+ and CD16+ in cured group before and after treatment were higher than those in the non-cure group, while the levels of CD8+ was lower than those in the non-cure group, the differences were statistically significant (P<0.05). Conclusion Peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning have detection significance, and peripheral blood immunoglobulin level and cellular immune function closely relate to the prognosis of children.
王智；何钦；林媛媛；刘小惠. 铅中毒患儿驱铅治疗后外周血免疫球蛋白水平及细胞免疫功能的检测意义[J]. 中国当代医药, 2022, 29(8): 95-98.
WANG Zhi； HE Qin； LIN Yuanyuan； LIU Xiaohui. Significance of detecting peripheral blood immunoglobulin level and cellular immune function in children with lead poisoning after antiplumbism. 中国当代医药, 2022, 29(8): 95-98.
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