Abstract:Objective To explore the clinical effect of Calcitriol in the treatment of Hashimoto thyroiditis.Methods A total of 110 patients with Hashimoto thyroiditis treared in Xincheng Hospital of Liaoyang Central Hospital selected from January 2019 to January 2021 were selected and divided into the control group and the observation group according to random number table method,with 55 cases in each group.The control group was treated with Levothyroxine Tablets,and the observation group was treated with Calcitriol on the basis of the control group.The clinical efficacy,thyroid hormone indexes,concentration of anti-thyroglobulin antibody (TGAb) and anti-thyroid peroxidase antibody (TPOAb)before and after treatment were compared between the two groups,and the adverse reactions during treatment were observed.Results The total clinical effective rate of the observation group was higher than that of the control group,the difference was statistically significant (P<0.05).The levels of free triiodothyronine (FT3) and free thyroxine (FT4) in the observation group after treatment were higher than those in the control group,and the levels of thyroid stimulating hormone (TSH),TGAb and TPOAb in the observation group after treatment were lower than those in the control group,the differences were statistically significant (P<0.05).During the treatment period,there were no adverse reactions such as blood routine,urine routine,liver and kidney function index lesions in the two groups.Conclusion The addition of Calcitriol on the basis of Levothyroxine Tablets in the treatment of Hashimoto thyroiditis can achieve significant clinical effects,can promote the improvement of thyroid hormone levels,adjust the concentration of TGAb and TPOAb,and there is no obvious adverse reaction during the treatment period,with high safety.
孙闯. 骨化三醇治疗桥本甲状腺炎的临床效果[J]. 中国当代医药, 2022, 29(7): 89-92.
SUN Chuang. Clinical effect of Calcitriol in the treatment of Hashimoto thyroiditis. 中国当代医药, 2022, 29(7): 89-92.
Okuroglu N,Ozdemir A,Sertbas Y,et al.The relationship between thyroid antibody titer and levothyroxine dose in patients with overt primary hypothyroidism[J].Ann Saudi Med,2017,37(3):189-193.