Abstract：Objective To investigate the therapeutic effect of low-dose Olanzapine combined with Venlafaxine on acute phase of patients with acute major depression.Methods A total of 94 patients with acute major depression admitted to the Fourth People′s Hospital of Yingkou City from May 2019 to May 2020 were selected as the research subjects.They were divided into study group and reference group by random number table method,with 47 patients in each group.The reference group was treated with Venlafaxine orally,while the study group was treated with low-dose Olanzapine on the basis of Venlafaxine.The Hamilton depression scale (HAMD) scores before treatment and at 2,4,8 and 16 weeks after treatment of the two groups were compared,the clinical efficacy and total incidence of adverse reactions in the two groups were compared.Results Before treatment,there were no significant differences in HAMD scores between the two groups (P＞0.05).HAMD scores of 2,4,8 and 16 weeks after treatment in the two groups were lower than those before treatment,the differences were statistically significant (P＜0.05).The HAMD scores at 2,4,8 and 16 weeks after treatment of the study group were lower than those of the reference group,with statistical significances (P＜0.05).The total effective rate of study group was higher than that of reference group,and the difference was statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05).Conclusion The combination of Venlafaxine and low-dose Olanzapine in the treatment of patients with acute major depression can improve the clinical treatment effect and help to control depressive symptoms more quickly without increasing adverse reactions
孙妍；林冬梅. 小剂量奥氮平联合文拉法辛对重度抑郁症急性期患者疗效的影响[J]. 中国当代医药, 2022, 29(7): 57-59转63.
SUN Yan；LIN Dongmei；. Therapeutic effect of low-dose Olanzapine combined with Venlafaxine on patients with acute major depression. 中国当代医药, 2022, 29(7): 57-59转63.
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