Objective To explore the effects of health education, traditional Chinese medicine nursing and psychological intervention on patients with chronic hepatitis B. Methods From January to December 2018, 100 patients with chronic hepatitis B treated in our hospital were selected as subject and divided as subjects into control group (n=50)and study group (n=50) according to random number table method. Health education and psychological intervention were carried out in the control group, on the basis of control group, the study group was combined with traditional Chinese medicine nursing. The psychological state and nursing satisfaction of the two groups before and after nursing were compared. Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before nursing in the study group were (61.75±2.60) and (61.85±2.85) points, respectively, and they were (61.80±2.55) and (61.90±2.80) points in the control group. There was no significant difference between the two groups (P＞0.05). After nursing,the SAS score and SDS score of the study group were (37.35±1.50) and (38.50±1.35) points, which were lower than those of the control group of (47.85±1.85) and (49.45±1.70) points, the differences were statistically significant (P<0.05). The total satisfaction rate of clinical nursing in the study group was 96.00%, which was higher than that in the control group (80.00%), the difference was statistically significant (P<0.05). Conclusion The effect of health education,traditional Chinese medicine nursing and psychological intervention on patients with chronic hepatitis B is accurate.